Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway

Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem cells...

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Detalles Bibliográficos
Autores principales: Ebrahim, Nesrine, Al Saihati, Hajir A., Mostafa, Ola, Hassouna, Amira, Abdulsamea, Sameh, Abd El Aziz M. El Gebaly, Eman, Abo-Rayah, Nashwa Hassan, Sabry, Dina, El-Sherbiny, Mohamed, Madboly, Abdelmonem G., Hussien, Noha Ibrahim, Saadani, Raja El Hasnaoui, Ebrahim, Hasnaa Ali, Badr, Omnia A. M., Elsherbiny, Nehal M., Salim, Rabab F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181089/
https://www.ncbi.nlm.nih.gov/pubmed/35682646
http://dx.doi.org/10.3390/ijms23115967

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