Cargando…

Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London

Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. The aim of this study was to assess the repr...

Descripción completa

Detalles Bibliográficos
Autores principales: Gaughran, Jonathan, Rosen O’Sullivan, Hannah, Lyne, Tom, Abdelbar, Ahmed, Abdalla, Mostafa, Sayasneh, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181136/
https://www.ncbi.nlm.nih.gov/pubmed/35683582
http://dx.doi.org/10.3390/jcm11113195
_version_ 1784723693856882688
author Gaughran, Jonathan
Rosen O’Sullivan, Hannah
Lyne, Tom
Abdelbar, Ahmed
Abdalla, Mostafa
Sayasneh, Ahmad
author_facet Gaughran, Jonathan
Rosen O’Sullivan, Hannah
Lyne, Tom
Abdelbar, Ahmed
Abdalla, Mostafa
Sayasneh, Ahmad
author_sort Gaughran, Jonathan
collection PubMed
description Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. The aim of this study was to assess the reproductive outcomes and prognosis of women who have undergone FSS for ovarian malignancy. Between 1 June 2008 and 1 June 2018, a retrospective review of a clinical database was conducted to identify all consecutive patients who underwent FSS in a central London gynaecological oncology centre. All patients with a histological diagnosis of ovarian malignancy (excluding borderline ovarian tumours) were eligible. All identified patients were then prospectively called into a follow up and asked to complete a questionnaire about their fertility outcomes. A total of 47 women underwent FSS; 36 were included in this study. The mean age was 30.3 years (95% Confidence Interval [CI]: 27.6 to 33.0 years). During the study period, 17/36 (47.2%) of the women had attempted to conceive following surgery, with a successful live birth rate of 52.9% (9/17). The mean time of recurrence was 125.3 months (95% CI: 106.5–144.1 months). The mean time to death was 139.5 months (95% CI: 124.3–154.8). The cancer grade, tumour stage and use of Assisted Reproductive Technology (ART) were the main factors significantly associated with the risk of recurrence and death. In conclusion, this study suggests that a large proportion of women will not attempt to conceive following FSS. For those who do attempt to conceive, the likelihood of achieving a live birth is high. However, careful counselling about the higher risk of recurrence and worse survival for women with high grade cancer, disease Stage > IA and potentially those who undergo ART is essential before contemplating FFS.
format Online
Article
Text
id pubmed-9181136
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91811362022-06-10 Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London Gaughran, Jonathan Rosen O’Sullivan, Hannah Lyne, Tom Abdelbar, Ahmed Abdalla, Mostafa Sayasneh, Ahmad J Clin Med Article Fertility Sparing Surgery (FSS) appears to be a safe means of treating early-stage ovarian cancer based on relatively limited evidence. However, there is currently insufficient evidence to aid women in counselling about their potential fertility outcomes. The aim of this study was to assess the reproductive outcomes and prognosis of women who have undergone FSS for ovarian malignancy. Between 1 June 2008 and 1 June 2018, a retrospective review of a clinical database was conducted to identify all consecutive patients who underwent FSS in a central London gynaecological oncology centre. All patients with a histological diagnosis of ovarian malignancy (excluding borderline ovarian tumours) were eligible. All identified patients were then prospectively called into a follow up and asked to complete a questionnaire about their fertility outcomes. A total of 47 women underwent FSS; 36 were included in this study. The mean age was 30.3 years (95% Confidence Interval [CI]: 27.6 to 33.0 years). During the study period, 17/36 (47.2%) of the women had attempted to conceive following surgery, with a successful live birth rate of 52.9% (9/17). The mean time of recurrence was 125.3 months (95% CI: 106.5–144.1 months). The mean time to death was 139.5 months (95% CI: 124.3–154.8). The cancer grade, tumour stage and use of Assisted Reproductive Technology (ART) were the main factors significantly associated with the risk of recurrence and death. In conclusion, this study suggests that a large proportion of women will not attempt to conceive following FSS. For those who do attempt to conceive, the likelihood of achieving a live birth is high. However, careful counselling about the higher risk of recurrence and worse survival for women with high grade cancer, disease Stage > IA and potentially those who undergo ART is essential before contemplating FFS. MDPI 2022-06-03 /pmc/articles/PMC9181136/ /pubmed/35683582 http://dx.doi.org/10.3390/jcm11113195 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gaughran, Jonathan
Rosen O’Sullivan, Hannah
Lyne, Tom
Abdelbar, Ahmed
Abdalla, Mostafa
Sayasneh, Ahmad
Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title_full Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title_fullStr Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title_full_unstemmed Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title_short Fertility Preserving Surgery Outcomes for Ovarian Malignancy: Data from a Tertiary Cancer Centre in Central London
title_sort fertility preserving surgery outcomes for ovarian malignancy: data from a tertiary cancer centre in central london
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181136/
https://www.ncbi.nlm.nih.gov/pubmed/35683582
http://dx.doi.org/10.3390/jcm11113195
work_keys_str_mv AT gaughranjonathan fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon
AT rosenosullivanhannah fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon
AT lynetom fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon
AT abdelbarahmed fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon
AT abdallamostafa fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon
AT sayasnehahmad fertilitypreservingsurgeryoutcomesforovarianmalignancydatafromatertiarycancercentreincentrallondon