Lymphatic Phenotype of Noonan Syndrome: Innovative Diagnosis and Possible Implications for Therapy

Dysregulation of the Ras/Mitogen-activated protein kinase (MAPK) signaling pathway is suggested to play a pivotal role in the development of the lymphatic system in patients with Noonan Syndrome (NS). Pathogenic gene variants in the Ras/MAPK pathway can therefore lead to various lymphatic diseases s...

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Detalles Bibliográficos
Autores principales: Kleimeier, Lotte E. R., van Schaik, Caroline, Leenders, Erika, Itkin, Maxim, Klein, Willemijn M., Draaisma, Jos M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181165/
https://www.ncbi.nlm.nih.gov/pubmed/35683512
http://dx.doi.org/10.3390/jcm11113128

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