The Effect of Conjugation of Ciprofloxacin and Moxifloxacin with Fatty Acids on Their Antibacterial and Anticancer Activity

Novel conjugates (CP) of moxifloxacin (MXF) with fatty acids (1m–16m) were synthesized with good yields utilizing amides chemistry. They exhibit a more pronounced cytotoxic potential than the parent drug. They were the most effective for prostate cancer cells with an IC(50) below 5 µM for respective...

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Detalles Bibliográficos
Autores principales: Chrzanowska, Alicja, Struga, Marta, Roszkowski, Piotr, Koliński, Michał, Kmiecik, Sebastian, Jałbrzykowska, Karolina, Zabost, Anna, Stefańska, Joanna, Augustynowicz-Kopeć, Ewa, Wrzosek, Małgorzata, Bielenica, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181188/
https://www.ncbi.nlm.nih.gov/pubmed/35682940
http://dx.doi.org/10.3390/ijms23116261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181188/
https://www.ncbi.nlm.nih.gov/pubmed/35682940
http://dx.doi.org/10.3390/ijms23116261

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