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An Insight into Recent Advances on Platelet Function in Health and Disease
Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181192/ https://www.ncbi.nlm.nih.gov/pubmed/35682700 http://dx.doi.org/10.3390/ijms23116022 |
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author | Chaudhary, Preeti Kumari Kim, Sanggu Kim, Soochong |
author_facet | Chaudhary, Preeti Kumari Kim, Sanggu Kim, Soochong |
author_sort | Chaudhary, Preeti Kumari |
collection | PubMed |
description | Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that have the ability to influence both physiological and pathophysiological processes including inflammation, tissue regeneration and repair, cancer progression, and spreading. The involvement of platelets in the progression and seriousness of a variety of disorders other than thrombosis is still being discovered, especially in the areas of inflammation and the immunological response. This review represents an integrated summary of recent advances on the function of platelets in pathophysiology that connects hemostasis, inflammation, and immunological response in health and disease and suggests that antiplatelet treatment might be used for more than only thrombosis. |
format | Online Article Text |
id | pubmed-9181192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91811922022-06-10 An Insight into Recent Advances on Platelet Function in Health and Disease Chaudhary, Preeti Kumari Kim, Sanggu Kim, Soochong Int J Mol Sci Review Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that have the ability to influence both physiological and pathophysiological processes including inflammation, tissue regeneration and repair, cancer progression, and spreading. The involvement of platelets in the progression and seriousness of a variety of disorders other than thrombosis is still being discovered, especially in the areas of inflammation and the immunological response. This review represents an integrated summary of recent advances on the function of platelets in pathophysiology that connects hemostasis, inflammation, and immunological response in health and disease and suggests that antiplatelet treatment might be used for more than only thrombosis. MDPI 2022-05-27 /pmc/articles/PMC9181192/ /pubmed/35682700 http://dx.doi.org/10.3390/ijms23116022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chaudhary, Preeti Kumari Kim, Sanggu Kim, Soochong An Insight into Recent Advances on Platelet Function in Health and Disease |
title | An Insight into Recent Advances on Platelet Function in Health and Disease |
title_full | An Insight into Recent Advances on Platelet Function in Health and Disease |
title_fullStr | An Insight into Recent Advances on Platelet Function in Health and Disease |
title_full_unstemmed | An Insight into Recent Advances on Platelet Function in Health and Disease |
title_short | An Insight into Recent Advances on Platelet Function in Health and Disease |
title_sort | insight into recent advances on platelet function in health and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181192/ https://www.ncbi.nlm.nih.gov/pubmed/35682700 http://dx.doi.org/10.3390/ijms23116022 |
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