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An Insight into Recent Advances on Platelet Function in Health and Disease

Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that h...

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Autores principales: Chaudhary, Preeti Kumari, Kim, Sanggu, Kim, Soochong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181192/
https://www.ncbi.nlm.nih.gov/pubmed/35682700
http://dx.doi.org/10.3390/ijms23116022
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author Chaudhary, Preeti Kumari
Kim, Sanggu
Kim, Soochong
author_facet Chaudhary, Preeti Kumari
Kim, Sanggu
Kim, Soochong
author_sort Chaudhary, Preeti Kumari
collection PubMed
description Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that have the ability to influence both physiological and pathophysiological processes including inflammation, tissue regeneration and repair, cancer progression, and spreading. The involvement of platelets in the progression and seriousness of a variety of disorders other than thrombosis is still being discovered, especially in the areas of inflammation and the immunological response. This review represents an integrated summary of recent advances on the function of platelets in pathophysiology that connects hemostasis, inflammation, and immunological response in health and disease and suggests that antiplatelet treatment might be used for more than only thrombosis.
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spelling pubmed-91811922022-06-10 An Insight into Recent Advances on Platelet Function in Health and Disease Chaudhary, Preeti Kumari Kim, Sanggu Kim, Soochong Int J Mol Sci Review Platelets play a variety of roles in vascular biology and are best recognized as primary hemostasis and thrombosis mediators. Platelets have a large number of receptors and secretory molecules that are required for platelet functionality. Upon activation, platelets release multiple substances that have the ability to influence both physiological and pathophysiological processes including inflammation, tissue regeneration and repair, cancer progression, and spreading. The involvement of platelets in the progression and seriousness of a variety of disorders other than thrombosis is still being discovered, especially in the areas of inflammation and the immunological response. This review represents an integrated summary of recent advances on the function of platelets in pathophysiology that connects hemostasis, inflammation, and immunological response in health and disease and suggests that antiplatelet treatment might be used for more than only thrombosis. MDPI 2022-05-27 /pmc/articles/PMC9181192/ /pubmed/35682700 http://dx.doi.org/10.3390/ijms23116022 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chaudhary, Preeti Kumari
Kim, Sanggu
Kim, Soochong
An Insight into Recent Advances on Platelet Function in Health and Disease
title An Insight into Recent Advances on Platelet Function in Health and Disease
title_full An Insight into Recent Advances on Platelet Function in Health and Disease
title_fullStr An Insight into Recent Advances on Platelet Function in Health and Disease
title_full_unstemmed An Insight into Recent Advances on Platelet Function in Health and Disease
title_short An Insight into Recent Advances on Platelet Function in Health and Disease
title_sort insight into recent advances on platelet function in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181192/
https://www.ncbi.nlm.nih.gov/pubmed/35682700
http://dx.doi.org/10.3390/ijms23116022
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