Prime Editing Permits the Introduction of Specific Mutations in the Gene Responsible for Duchenne Muscular Dystrophy

The Prime editing technique derived from the CRISPR/Cas9 discovery permits the modification of selected nucleotides in a specific gene. We used it to insert specific point mutations in exons 9, 20, 35, 43, 55 and 61 of the Duchenne Muscular Dystrophy (DMD) gene coding for the dystrophin protein, whi...

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Detalles Bibliográficos
Autores principales: Happi Mbakam, Cédric, Rousseau, Joël, Tremblay, Guillaume, Yameogo, Pouiré, Tremblay, Jacques P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181224/
https://www.ncbi.nlm.nih.gov/pubmed/35682838
http://dx.doi.org/10.3390/ijms23116160

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