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Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold

Malignant Pleural Mesothelioma (MPM) is a highly aggressive disease whose diagnosis could be challenging and confusing. It could occur with atypical presentations on every examined level. Here, we present three unconventional cases of the complex diagnostic process of MPM that we have experienced du...

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Autores principales: Orlandi, Riccardo, Bono, Francesca, Cortinovis, Diego Luigi, Cardillo, Giuseppe, Cioffi, Ugo, Guttadauro, Angelo, Pirondini, Emanuele, Canova, Stefania, Cassina, Enrico Mario, Raveglia, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181256/
https://www.ncbi.nlm.nih.gov/pubmed/35683612
http://dx.doi.org/10.3390/jcm11113225
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author Orlandi, Riccardo
Bono, Francesca
Cortinovis, Diego Luigi
Cardillo, Giuseppe
Cioffi, Ugo
Guttadauro, Angelo
Pirondini, Emanuele
Canova, Stefania
Cassina, Enrico Mario
Raveglia, Federico
author_facet Orlandi, Riccardo
Bono, Francesca
Cortinovis, Diego Luigi
Cardillo, Giuseppe
Cioffi, Ugo
Guttadauro, Angelo
Pirondini, Emanuele
Canova, Stefania
Cassina, Enrico Mario
Raveglia, Federico
author_sort Orlandi, Riccardo
collection PubMed
description Malignant Pleural Mesothelioma (MPM) is a highly aggressive disease whose diagnosis could be challenging and confusing. It could occur with atypical presentations on every examined level. Here, we present three unconventional cases of the complex diagnostic process of MPM that we have experienced during routine practice: a patient with reactive mesothelial hyperplasia mimicking MPM, an unexpected presentation of MPM with persistent unilateral hydropneumothorax, a rare case of MPM in situ. Then, we review the relevant literature on each of these topics. Definitive biomarkers to confidently distinguish MPM from other pleural affections are still demanded. Patients presenting with persistent hydropneumothorax must always be investigated for MPM. MPM in situ is now a reality, and this raises questions about its management.
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spelling pubmed-91812562022-06-10 Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold Orlandi, Riccardo Bono, Francesca Cortinovis, Diego Luigi Cardillo, Giuseppe Cioffi, Ugo Guttadauro, Angelo Pirondini, Emanuele Canova, Stefania Cassina, Enrico Mario Raveglia, Federico J Clin Med Article Malignant Pleural Mesothelioma (MPM) is a highly aggressive disease whose diagnosis could be challenging and confusing. It could occur with atypical presentations on every examined level. Here, we present three unconventional cases of the complex diagnostic process of MPM that we have experienced during routine practice: a patient with reactive mesothelial hyperplasia mimicking MPM, an unexpected presentation of MPM with persistent unilateral hydropneumothorax, a rare case of MPM in situ. Then, we review the relevant literature on each of these topics. Definitive biomarkers to confidently distinguish MPM from other pleural affections are still demanded. Patients presenting with persistent hydropneumothorax must always be investigated for MPM. MPM in situ is now a reality, and this raises questions about its management. MDPI 2022-06-06 /pmc/articles/PMC9181256/ /pubmed/35683612 http://dx.doi.org/10.3390/jcm11113225 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Orlandi, Riccardo
Bono, Francesca
Cortinovis, Diego Luigi
Cardillo, Giuseppe
Cioffi, Ugo
Guttadauro, Angelo
Pirondini, Emanuele
Canova, Stefania
Cassina, Enrico Mario
Raveglia, Federico
Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title_full Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title_fullStr Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title_full_unstemmed Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title_short Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
title_sort sneaky diagnosis of pleural malignant mesothelioma in thoracic surgery: all that glitters is not gold
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181256/
https://www.ncbi.nlm.nih.gov/pubmed/35683612
http://dx.doi.org/10.3390/jcm11113225
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