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Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy

(1) Background: we aimed to describe the disease-specific quality of life (QoL) of ischemic stroke patients treated with acute revascularization therapy, its evolution from 6 months to 12 months, and associated factors. (2) Methods: QoL was assessed with the SS-QoL in consecutive patients treated wi...

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Autores principales: Do Rego, Aboudou Matinou, Duloquin, Gauthier, Sauvant, Marie, Amaral, Simon, Thomas, Quentin, Devilliers, Hervé, Béjot, Yannick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181285/
https://www.ncbi.nlm.nih.gov/pubmed/35683624
http://dx.doi.org/10.3390/jcm11113240
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author Do Rego, Aboudou Matinou
Duloquin, Gauthier
Sauvant, Marie
Amaral, Simon
Thomas, Quentin
Devilliers, Hervé
Béjot, Yannick
author_facet Do Rego, Aboudou Matinou
Duloquin, Gauthier
Sauvant, Marie
Amaral, Simon
Thomas, Quentin
Devilliers, Hervé
Béjot, Yannick
author_sort Do Rego, Aboudou Matinou
collection PubMed
description (1) Background: we aimed to describe the disease-specific quality of life (QoL) of ischemic stroke patients treated with acute revascularization therapy, its evolution from 6 months to 12 months, and associated factors. (2) Methods: QoL was assessed with the SS-QoL in consecutive patients treated with either intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT). Variables associated with QoL scores and its evolution were studied using multivariate mixed models, and interaction with time. Analyses were performed in four domains of SS-QoL: self-care, mobility, mood, and social roles. (3) Results: Among the 501 included patients (mean (sd) age 68.9 (14.5), 49% women), lower post-stroke QoL was independently related to lower level of school education, prestroke mRS > 2, and 24 h NIHSS score > 4. Independent predictors of unfavorable evolution of QoL over time were age <75 years (Mobility p = 0.0194 and Mood p = 0.0015), NIHSS score ≤ 4, (Self-care p = 0.0053 and Mood p = 0.0048), and modified Rankin Scale score ≤ 2 (Social roles, p = 0.0006). Revascularization therapy had no significant effect on the QoL scores, but patients treated with MT (alone or as bridging therapy) had significantly greater improvement in mobility score between 6 and 12 months than patients treated with IVT alone (p = 0.0072). (4) Conclusion: QoL evolution over one year had only slight variation and was associated with the modalities of acute treatment, age, and stroke severity.
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spelling pubmed-91812852022-06-10 Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy Do Rego, Aboudou Matinou Duloquin, Gauthier Sauvant, Marie Amaral, Simon Thomas, Quentin Devilliers, Hervé Béjot, Yannick J Clin Med Article (1) Background: we aimed to describe the disease-specific quality of life (QoL) of ischemic stroke patients treated with acute revascularization therapy, its evolution from 6 months to 12 months, and associated factors. (2) Methods: QoL was assessed with the SS-QoL in consecutive patients treated with either intravenous thrombolysis (IVT) and/or mechanical thrombectomy (MT). Variables associated with QoL scores and its evolution were studied using multivariate mixed models, and interaction with time. Analyses were performed in four domains of SS-QoL: self-care, mobility, mood, and social roles. (3) Results: Among the 501 included patients (mean (sd) age 68.9 (14.5), 49% women), lower post-stroke QoL was independently related to lower level of school education, prestroke mRS > 2, and 24 h NIHSS score > 4. Independent predictors of unfavorable evolution of QoL over time were age <75 years (Mobility p = 0.0194 and Mood p = 0.0015), NIHSS score ≤ 4, (Self-care p = 0.0053 and Mood p = 0.0048), and modified Rankin Scale score ≤ 2 (Social roles, p = 0.0006). Revascularization therapy had no significant effect on the QoL scores, but patients treated with MT (alone or as bridging therapy) had significantly greater improvement in mobility score between 6 and 12 months than patients treated with IVT alone (p = 0.0072). (4) Conclusion: QoL evolution over one year had only slight variation and was associated with the modalities of acute treatment, age, and stroke severity. MDPI 2022-06-06 /pmc/articles/PMC9181285/ /pubmed/35683624 http://dx.doi.org/10.3390/jcm11113240 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Do Rego, Aboudou Matinou
Duloquin, Gauthier
Sauvant, Marie
Amaral, Simon
Thomas, Quentin
Devilliers, Hervé
Béjot, Yannick
Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title_full Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title_fullStr Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title_full_unstemmed Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title_short Quality of Life in the First Year after Ischemic Stroke Treated with Acute Revascularization Therapy
title_sort quality of life in the first year after ischemic stroke treated with acute revascularization therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181285/
https://www.ncbi.nlm.nih.gov/pubmed/35683624
http://dx.doi.org/10.3390/jcm11113240
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