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Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum
The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa’s Gauteng region...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181312/ https://www.ncbi.nlm.nih.gov/pubmed/35772405 http://dx.doi.org/10.1016/j.cell.2022.06.005 |
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| author | Tuekprakhon, Aekkachai Nutalai, Rungtiwa Dijokaite-Guraliuc, Aiste Zhou, Daming Ginn, Helen M. Selvaraj, Muneeswaran Liu, Chang Mentzer, Alexander J. Supasa, Piyada Duyvesteyn, Helen M.E. Das, Raksha Skelly, Donal Ritter, Thomas G. Amini, Ali Bibi, Sagida Adele, Sandra Johnson, Sile Ann Constantinides, Bede Webster, Hermione Temperton, Nigel Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Crook, Derrick Pollard, Andrew J. Lambe, Teresa Goulder, Philip Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Huo, Jiandong Mongkolsapaya, Juthathip Ren, Jingshan Stuart, David I. Screaton, Gavin R. |
| author_facet | Tuekprakhon, Aekkachai Nutalai, Rungtiwa Dijokaite-Guraliuc, Aiste Zhou, Daming Ginn, Helen M. Selvaraj, Muneeswaran Liu, Chang Mentzer, Alexander J. Supasa, Piyada Duyvesteyn, Helen M.E. Das, Raksha Skelly, Donal Ritter, Thomas G. Amini, Ali Bibi, Sagida Adele, Sandra Johnson, Sile Ann Constantinides, Bede Webster, Hermione Temperton, Nigel Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Crook, Derrick Pollard, Andrew J. Lambe, Teresa Goulder, Philip Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Huo, Jiandong Mongkolsapaya, Juthathip Ren, Jingshan Stuart, David I. Screaton, Gavin R. |
| author_sort | Tuekprakhon, Aekkachai |
| collection | PubMed |
| description | The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa’s Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced neutralization by the serum from individuals vaccinated with triple doses of AstraZeneca or Pfizer vaccine compared with BA.1 and BA.2. Furthermore, using the serum from BA.1 vaccine breakthrough infections, there are, likewise, significant reductions in the neutralization of BA.4/5, raising the possibility of repeat Omicron infections. |
| format | Online Article Text |
| id | pubmed-9181312 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-91813122022-06-10 Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum Tuekprakhon, Aekkachai Nutalai, Rungtiwa Dijokaite-Guraliuc, Aiste Zhou, Daming Ginn, Helen M. Selvaraj, Muneeswaran Liu, Chang Mentzer, Alexander J. Supasa, Piyada Duyvesteyn, Helen M.E. Das, Raksha Skelly, Donal Ritter, Thomas G. Amini, Ali Bibi, Sagida Adele, Sandra Johnson, Sile Ann Constantinides, Bede Webster, Hermione Temperton, Nigel Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Crook, Derrick Pollard, Andrew J. Lambe, Teresa Goulder, Philip Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Huo, Jiandong Mongkolsapaya, Juthathip Ren, Jingshan Stuart, David I. Screaton, Gavin R. Cell Article The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial wave but has been replaced by BA.2 in many countries. Recent sequencing from South Africa’s Gauteng region uncovered two new sublineages, BA.4 and BA.5, which are taking over locally, driving a new wave. BA.4 and BA.5 contain identical spike sequences, and although closely related to BA.2, they contain further mutations in the receptor-binding domain of their spikes. Here, we study the neutralization of BA.4/5 using a range of vaccine and naturally immune serum and panels of monoclonal antibodies. BA.4/5 shows reduced neutralization by the serum from individuals vaccinated with triple doses of AstraZeneca or Pfizer vaccine compared with BA.1 and BA.2. Furthermore, using the serum from BA.1 vaccine breakthrough infections, there are, likewise, significant reductions in the neutralization of BA.4/5, raising the possibility of repeat Omicron infections. Cell Press 2022-07-07 /pmc/articles/PMC9181312/ /pubmed/35772405 http://dx.doi.org/10.1016/j.cell.2022.06.005 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Tuekprakhon, Aekkachai Nutalai, Rungtiwa Dijokaite-Guraliuc, Aiste Zhou, Daming Ginn, Helen M. Selvaraj, Muneeswaran Liu, Chang Mentzer, Alexander J. Supasa, Piyada Duyvesteyn, Helen M.E. Das, Raksha Skelly, Donal Ritter, Thomas G. Amini, Ali Bibi, Sagida Adele, Sandra Johnson, Sile Ann Constantinides, Bede Webster, Hermione Temperton, Nigel Klenerman, Paul Barnes, Eleanor Dunachie, Susanna J. Crook, Derrick Pollard, Andrew J. Lambe, Teresa Goulder, Philip Paterson, Neil G. Williams, Mark A. Hall, David R. Fry, Elizabeth E. Huo, Jiandong Mongkolsapaya, Juthathip Ren, Jingshan Stuart, David I. Screaton, Gavin R. Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title_full | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title_fullStr | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title_full_unstemmed | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title_short | Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum |
| title_sort | antibody escape of sars-cov-2 omicron ba.4 and ba.5 from vaccine and ba.1 serum |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181312/ https://www.ncbi.nlm.nih.gov/pubmed/35772405 http://dx.doi.org/10.1016/j.cell.2022.06.005 |
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