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Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis

Aims: The present study aims to evaluate magnetic-resonance-imaging (MRI)-assessed left atrial strain (LAS) and left atrial strain rate (LASR) as potential parameters for the diagnosis of cardiac amyloidosis (CA), the distinction of clinical subtypes and differentiation from other cardiomyopathies....

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Autores principales: Sciacca, Vanessa, Eckstein, Jan, Körperich, Hermann, Fink, Thomas, Bergau, Leonard, El Hamriti, Mustapha, Imnadze, Guram, Guckel, Denise, Fox, Henrik, Gerçek, Muhammed, Farr, Martin, Burchert, Wolfgang, Sommer, Philipp, Sohns, Christian, Piran, Misagh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181318/
https://www.ncbi.nlm.nih.gov/pubmed/35683537
http://dx.doi.org/10.3390/jcm11113150
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author Sciacca, Vanessa
Eckstein, Jan
Körperich, Hermann
Fink, Thomas
Bergau, Leonard
El Hamriti, Mustapha
Imnadze, Guram
Guckel, Denise
Fox, Henrik
Gerçek, Muhammed
Farr, Martin
Burchert, Wolfgang
Sommer, Philipp
Sohns, Christian
Piran, Misagh
author_facet Sciacca, Vanessa
Eckstein, Jan
Körperich, Hermann
Fink, Thomas
Bergau, Leonard
El Hamriti, Mustapha
Imnadze, Guram
Guckel, Denise
Fox, Henrik
Gerçek, Muhammed
Farr, Martin
Burchert, Wolfgang
Sommer, Philipp
Sohns, Christian
Piran, Misagh
author_sort Sciacca, Vanessa
collection PubMed
description Aims: The present study aims to evaluate magnetic-resonance-imaging (MRI)-assessed left atrial strain (LAS) and left atrial strain rate (LASR) as potential parameters for the diagnosis of cardiac amyloidosis (CA), the distinction of clinical subtypes and differentiation from other cardiomyopathies. Methods and results: LAS and LASR were assessed by MRI feature tracking in patients with biopsy-proven CA. LAS and LASR of patients with CA were compared to healthy subjects and patients with hypertrophic cardiomyopathy. LAS and LASR were also analyzed concerning differences between patients with transthyretin (ATTR) and light chain amyloidosis (AL). A total of 44 patients with biopsy-proven CA, 19 patients with hypertrophic cardiomyopathy and 24 healthy subjects were included. In 22 CA patients (50%), histological examination identified ATTR as CA subtype and AL in the remaining patients. No significant difference was observed for reservoir, conduit or booster LAS in patients with AL or ATTR. Reservoir LAS, conduit LAS and booster LAS were significantly reduced in patients with CA and HCM as compared to healthy subjects (p < 0.001). Reservoir LAS and booster LAS were significantly reduced in CA as compared to HCM patients (p < 0.001). A linear correlation was observed between LA global reservoir strain and LA-EF (p < 0.001, r = 0.5), conduit strain and global longitudinal LV strain (p < 0.001, r = 0.5), global booster strain rate and LA-EF (p < 0.001, r = 0.6) and between global booster strain rate and LA area at LVED (p < 0.0001, 0.5). Conclusions: LAS and LASR are severely impaired in patients with CA. The MRI-based assessment of LAS and LASR might allow non-invasive diagnosis and categorization of CA and its distinct differentiation from other hypertrophic phenotypes.
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spelling pubmed-91813182022-06-10 Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis Sciacca, Vanessa Eckstein, Jan Körperich, Hermann Fink, Thomas Bergau, Leonard El Hamriti, Mustapha Imnadze, Guram Guckel, Denise Fox, Henrik Gerçek, Muhammed Farr, Martin Burchert, Wolfgang Sommer, Philipp Sohns, Christian Piran, Misagh J Clin Med Article Aims: The present study aims to evaluate magnetic-resonance-imaging (MRI)-assessed left atrial strain (LAS) and left atrial strain rate (LASR) as potential parameters for the diagnosis of cardiac amyloidosis (CA), the distinction of clinical subtypes and differentiation from other cardiomyopathies. Methods and results: LAS and LASR were assessed by MRI feature tracking in patients with biopsy-proven CA. LAS and LASR of patients with CA were compared to healthy subjects and patients with hypertrophic cardiomyopathy. LAS and LASR were also analyzed concerning differences between patients with transthyretin (ATTR) and light chain amyloidosis (AL). A total of 44 patients with biopsy-proven CA, 19 patients with hypertrophic cardiomyopathy and 24 healthy subjects were included. In 22 CA patients (50%), histological examination identified ATTR as CA subtype and AL in the remaining patients. No significant difference was observed for reservoir, conduit or booster LAS in patients with AL or ATTR. Reservoir LAS, conduit LAS and booster LAS were significantly reduced in patients with CA and HCM as compared to healthy subjects (p < 0.001). Reservoir LAS and booster LAS were significantly reduced in CA as compared to HCM patients (p < 0.001). A linear correlation was observed between LA global reservoir strain and LA-EF (p < 0.001, r = 0.5), conduit strain and global longitudinal LV strain (p < 0.001, r = 0.5), global booster strain rate and LA-EF (p < 0.001, r = 0.6) and between global booster strain rate and LA area at LVED (p < 0.0001, 0.5). Conclusions: LAS and LASR are severely impaired in patients with CA. The MRI-based assessment of LAS and LASR might allow non-invasive diagnosis and categorization of CA and its distinct differentiation from other hypertrophic phenotypes. MDPI 2022-06-01 /pmc/articles/PMC9181318/ /pubmed/35683537 http://dx.doi.org/10.3390/jcm11113150 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sciacca, Vanessa
Eckstein, Jan
Körperich, Hermann
Fink, Thomas
Bergau, Leonard
El Hamriti, Mustapha
Imnadze, Guram
Guckel, Denise
Fox, Henrik
Gerçek, Muhammed
Farr, Martin
Burchert, Wolfgang
Sommer, Philipp
Sohns, Christian
Piran, Misagh
Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title_full Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title_fullStr Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title_full_unstemmed Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title_short Magnetic-Resonance-Imaging-Based Left Atrial Strain and Left Atrial Strain Rate as Diagnostic Parameters in Cardiac Amyloidosis
title_sort magnetic-resonance-imaging-based left atrial strain and left atrial strain rate as diagnostic parameters in cardiac amyloidosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181318/
https://www.ncbi.nlm.nih.gov/pubmed/35683537
http://dx.doi.org/10.3390/jcm11113150
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