Haploinsufficiency of a Circadian Clock Gene Bmal1 (Arntl or Mop3) Causes Brain-Wide mTOR Hyperactivation and Autism-like Behavioral Phenotypes in Mice

Approximately 50–80% of children with autism spectrum disorders (ASDs) exhibit sleep problems, but the contribution of circadian clock dysfunction to the development of ASDs remains largely unknown. The essential clock gene Bmal1 (Arntl or Mop3) has been associated with human sociability, and its mi...

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Detalles Bibliográficos
Autores principales: Singla, Rubal, Mishra, Abhishek, Lin, Hao, Lorsung, Ethan, Le, Nam, Tin, Su, Jin, Victor X., Cao, Ruifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181331/
https://www.ncbi.nlm.nih.gov/pubmed/35682995
http://dx.doi.org/10.3390/ijms23116317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181331/
https://www.ncbi.nlm.nih.gov/pubmed/35682995
http://dx.doi.org/10.3390/ijms23116317

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