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Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181340/ https://www.ncbi.nlm.nih.gov/pubmed/35682722 http://dx.doi.org/10.3390/ijms23116047 |
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author | Cheng, Tsai-Chin Huang, Shou-Hsien Kao, Chung-Lan Hsu, Po-Cheng |
author_facet | Cheng, Tsai-Chin Huang, Shou-Hsien Kao, Chung-Lan Hsu, Po-Cheng |
author_sort | Cheng, Tsai-Chin |
collection | PubMed |
description | Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology. |
format | Online Article Text |
id | pubmed-9181340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91813402022-06-10 Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review Cheng, Tsai-Chin Huang, Shou-Hsien Kao, Chung-Lan Hsu, Po-Cheng Int J Mol Sci Review Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology. MDPI 2022-05-27 /pmc/articles/PMC9181340/ /pubmed/35682722 http://dx.doi.org/10.3390/ijms23116047 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cheng, Tsai-Chin Huang, Shou-Hsien Kao, Chung-Lan Hsu, Po-Cheng Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title_full | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title_fullStr | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title_full_unstemmed | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title_short | Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review |
title_sort | muscle wasting in chronic kidney disease: mechanism and clinical implications—a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181340/ https://www.ncbi.nlm.nih.gov/pubmed/35682722 http://dx.doi.org/10.3390/ijms23116047 |
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