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Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review

Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In t...

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Detalles Bibliográficos
Autores principales: Cheng, Tsai-Chin, Huang, Shou-Hsien, Kao, Chung-Lan, Hsu, Po-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181340/
https://www.ncbi.nlm.nih.gov/pubmed/35682722
http://dx.doi.org/10.3390/ijms23116047
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author Cheng, Tsai-Chin
Huang, Shou-Hsien
Kao, Chung-Lan
Hsu, Po-Cheng
author_facet Cheng, Tsai-Chin
Huang, Shou-Hsien
Kao, Chung-Lan
Hsu, Po-Cheng
author_sort Cheng, Tsai-Chin
collection PubMed
description Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology.
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spelling pubmed-91813402022-06-10 Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review Cheng, Tsai-Chin Huang, Shou-Hsien Kao, Chung-Lan Hsu, Po-Cheng Int J Mol Sci Review Muscle wasting, known to develop in patients with chronic kidney disease (CKD), is a deleterious consequence of numerous complications associated with deteriorated renal function. Muscle wasting in CKD mainly involves dysregulated muscle protein metabolism and impaired muscle cell regeneration. In this narrative review, we discuss the cardinal role of the insulin-like growth factor 1 and myostatin signaling pathways, which have been extensively investigated using animal and human studies, as well as the emerging concepts in microRNA- and gut microbiota-mediated regulation of muscle mass and myogenesis. To ameliorate muscle loss, therapeutic strategies, including nutritional support, exercise programs, pharmacological interventions, and physical modalities, are being increasingly developed based on advances in understanding its underlying pathophysiology. MDPI 2022-05-27 /pmc/articles/PMC9181340/ /pubmed/35682722 http://dx.doi.org/10.3390/ijms23116047 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cheng, Tsai-Chin
Huang, Shou-Hsien
Kao, Chung-Lan
Hsu, Po-Cheng
Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title_full Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title_fullStr Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title_full_unstemmed Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title_short Muscle Wasting in Chronic Kidney Disease: Mechanism and Clinical Implications—A Narrative Review
title_sort muscle wasting in chronic kidney disease: mechanism and clinical implications—a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181340/
https://www.ncbi.nlm.nih.gov/pubmed/35682722
http://dx.doi.org/10.3390/ijms23116047
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