Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease

RNA viruses are critically dependent upon virally encoded proteases to cleave the viral polyproteins into functional proteins. Many of these proteases exhibit a similar fold and contain an essential catalytic cysteine, offering the opportunity to inhibit these enzymes with electrophilic small molecu...

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Detalles Bibliográficos
Autores principales: Qin, Bo, Craven, Gregory B., Hou, Pengjiao, Chesti, Julian, Lu, Xinran, Child, Emma S., Morgan, Rhodri M.L., Niu, Wenchao, Zhao, Lina, Armstrong, Alan, Mann, David J., Cui, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181371/
https://www.ncbi.nlm.nih.gov/pubmed/35702321
http://dx.doi.org/10.1016/j.apsb.2022.06.002

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