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Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities
Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181380/ https://www.ncbi.nlm.nih.gov/pubmed/35682715 http://dx.doi.org/10.3390/ijms23116031 |
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author | Osmakov, Dmitry I. Kalinovskii, Aleksandr P. Belozerova, Olga A. Andreev, Yaroslav A. Kozlov, Sergey A. |
author_facet | Osmakov, Dmitry I. Kalinovskii, Aleksandr P. Belozerova, Olga A. Andreev, Yaroslav A. Kozlov, Sergey A. |
author_sort | Osmakov, Dmitry I. |
collection | PubMed |
description | Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022. |
format | Online Article Text |
id | pubmed-9181380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91813802022-06-10 Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities Osmakov, Dmitry I. Kalinovskii, Aleksandr P. Belozerova, Olga A. Andreev, Yaroslav A. Kozlov, Sergey A. Int J Mol Sci Review Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022. MDPI 2022-05-27 /pmc/articles/PMC9181380/ /pubmed/35682715 http://dx.doi.org/10.3390/ijms23116031 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Osmakov, Dmitry I. Kalinovskii, Aleksandr P. Belozerova, Olga A. Andreev, Yaroslav A. Kozlov, Sergey A. Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title | Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title_full | Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title_fullStr | Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title_full_unstemmed | Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title_short | Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities |
title_sort | lignans as pharmacological agents in disorders related to oxidative stress and inflammation: chemical synthesis approaches and biological activities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181380/ https://www.ncbi.nlm.nih.gov/pubmed/35682715 http://dx.doi.org/10.3390/ijms23116031 |
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