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New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents

Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful too...

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Autores principales: Chen, Kuo-Ting, Seimbille, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181387/
https://www.ncbi.nlm.nih.gov/pubmed/35682802
http://dx.doi.org/10.3390/ijms23116125
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author Chen, Kuo-Ting
Seimbille, Yann
author_facet Chen, Kuo-Ting
Seimbille, Yann
author_sort Chen, Kuo-Ting
collection PubMed
description Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed.
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spelling pubmed-91813872022-06-10 New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents Chen, Kuo-Ting Seimbille, Yann Int J Mol Sci Review Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the molecular imaging of solid malignancies. The nuclear- and optical-imaging of CAIX-expressing tumors have received great attention due to their potential for clinical applications. Nuclear imaging is a powerful tool for the non-invasive diagnosis of primary and metastatic CAIX-positive tumors and for the assessment of responses to antineoplastic treatment. Intraoperative optical fluorescence imaging provides improved visualization for surgeons to increase the discrimination of tumor lesions, allowing for safer surgical treatment. Over the past decades, many CAIX-targeted molecular imaging probes, based on monoclonal antibodies, antibody fragments, peptides, and small molecules, have been reported. In this review, we outline the recent development of CAIX-targeted probes for single-photon emission computerized tomography (SPECT), positron emission tomography (PET), and near-infrared fluorescence imaging (NIRF), and we discuss issues yet to be addressed. MDPI 2022-05-30 /pmc/articles/PMC9181387/ /pubmed/35682802 http://dx.doi.org/10.3390/ijms23116125 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Kuo-Ting
Seimbille, Yann
New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title_full New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title_fullStr New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title_full_unstemmed New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title_short New Developments in Carbonic Anhydrase IX-Targeted Fluorescence and Nuclear Imaging Agents
title_sort new developments in carbonic anhydrase ix-targeted fluorescence and nuclear imaging agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181387/
https://www.ncbi.nlm.nih.gov/pubmed/35682802
http://dx.doi.org/10.3390/ijms23116125
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