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Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever
The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181393/ https://www.ncbi.nlm.nih.gov/pubmed/35690330 http://dx.doi.org/10.1016/j.phrs.2022.106293 |
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author | Marinelli, Francesca Caporilli, Chiara Titolo, Annachiara Rigante, Donato Esposito, Susanna |
author_facet | Marinelli, Francesca Caporilli, Chiara Titolo, Annachiara Rigante, Donato Esposito, Susanna |
author_sort | Marinelli, Francesca |
collection | PubMed |
description | The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population. |
format | Online Article Text |
id | pubmed-9181393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91813932022-06-10 Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever Marinelli, Francesca Caporilli, Chiara Titolo, Annachiara Rigante, Donato Esposito, Susanna Pharmacol Res Article The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population. Elsevier Ltd. 2022-08 2022-06-09 /pmc/articles/PMC9181393/ /pubmed/35690330 http://dx.doi.org/10.1016/j.phrs.2022.106293 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Marinelli, Francesca Caporilli, Chiara Titolo, Annachiara Rigante, Donato Esposito, Susanna Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title | Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title_full | Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title_fullStr | Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title_full_unstemmed | Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title_short | Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever |
title_sort | clinical impact and disease evolution of sars-cov-2 infection in familial mediterranean fever |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181393/ https://www.ncbi.nlm.nih.gov/pubmed/35690330 http://dx.doi.org/10.1016/j.phrs.2022.106293 |
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