Cargando…

Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients

Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanellias, Nikolaos, Ntanasis-Stathopoulos, Ioannis, Gavriatopoulou, Maria, Koutoulidis, Vassilis, Fotiou, Despina, Migkou, Magdalini, Eleutherakis-Papaiakovou, Evangelos, Malandrakis, Panagiotis, Bagratuni, Tina, Mavropoulos-Papoudas, Stylianos, Roussou, Maria, Kastritis, Efstathios, Moulopoulos, Lia A., Dimopoulos, Meletios A., Terpos, Evangelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181401/
https://www.ncbi.nlm.nih.gov/pubmed/35683473
http://dx.doi.org/10.3390/jcm11113088
_version_ 1784723762163220480
author Kanellias, Nikolaos
Ntanasis-Stathopoulos, Ioannis
Gavriatopoulou, Maria
Koutoulidis, Vassilis
Fotiou, Despina
Migkou, Magdalini
Eleutherakis-Papaiakovou, Evangelos
Malandrakis, Panagiotis
Bagratuni, Tina
Mavropoulos-Papoudas, Stylianos
Roussou, Maria
Kastritis, Efstathios
Moulopoulos, Lia A.
Dimopoulos, Meletios A.
Terpos, Evangelos
author_facet Kanellias, Nikolaos
Ntanasis-Stathopoulos, Ioannis
Gavriatopoulou, Maria
Koutoulidis, Vassilis
Fotiou, Despina
Migkou, Magdalini
Eleutherakis-Papaiakovou, Evangelos
Malandrakis, Panagiotis
Bagratuni, Tina
Mavropoulos-Papoudas, Stylianos
Roussou, Maria
Kastritis, Efstathios
Moulopoulos, Lia A.
Dimopoulos, Meletios A.
Terpos, Evangelos
author_sort Kanellias, Nikolaos
collection PubMed
description Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among newly diagnosed MMs (NDMM) and to explore the possible correlations with disease characteristics, imaging finding, and patient prognosis. A total of 370 patients with available baseline MRIs were included. Among them, 208 (56%) presented with at least one SRE at diagnosis. Fractures were the most common reported SREs (48%). The incidence of SREs at diagnosis was higher in patients with osteolytic lesions, abnormal MRI pattern, hypercalcemia, and at least 60% bone marrow infiltration by plasma cells. Importantly, the patients with normal MRI pattern, who did not present with SREs at diagnosis, had statistically significant improved median OS in comparison with the patients who had abnormal MRI patterns and/or the presence of SREs at diagnosis (9.3 vs. 6.6 years, p = 0.048). Our data, which represent one of a few systematic reports on the incidence and characteristics of SREs in the era of novel agents, was indicative of a high incidence of SREs at the time of MM diagnosis. Early detection of myeloma bone disease and tailored patient management are essential to optimize patient outcomes.
format Online
Article
Text
id pubmed-9181401
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-91814012022-06-10 Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients Kanellias, Nikolaos Ntanasis-Stathopoulos, Ioannis Gavriatopoulou, Maria Koutoulidis, Vassilis Fotiou, Despina Migkou, Magdalini Eleutherakis-Papaiakovou, Evangelos Malandrakis, Panagiotis Bagratuni, Tina Mavropoulos-Papoudas, Stylianos Roussou, Maria Kastritis, Efstathios Moulopoulos, Lia A. Dimopoulos, Meletios A. Terpos, Evangelos J Clin Med Article Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among newly diagnosed MMs (NDMM) and to explore the possible correlations with disease characteristics, imaging finding, and patient prognosis. A total of 370 patients with available baseline MRIs were included. Among them, 208 (56%) presented with at least one SRE at diagnosis. Fractures were the most common reported SREs (48%). The incidence of SREs at diagnosis was higher in patients with osteolytic lesions, abnormal MRI pattern, hypercalcemia, and at least 60% bone marrow infiltration by plasma cells. Importantly, the patients with normal MRI pattern, who did not present with SREs at diagnosis, had statistically significant improved median OS in comparison with the patients who had abnormal MRI patterns and/or the presence of SREs at diagnosis (9.3 vs. 6.6 years, p = 0.048). Our data, which represent one of a few systematic reports on the incidence and characteristics of SREs in the era of novel agents, was indicative of a high incidence of SREs at the time of MM diagnosis. Early detection of myeloma bone disease and tailored patient management are essential to optimize patient outcomes. MDPI 2022-05-30 /pmc/articles/PMC9181401/ /pubmed/35683473 http://dx.doi.org/10.3390/jcm11113088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanellias, Nikolaos
Ntanasis-Stathopoulos, Ioannis
Gavriatopoulou, Maria
Koutoulidis, Vassilis
Fotiou, Despina
Migkou, Magdalini
Eleutherakis-Papaiakovou, Evangelos
Malandrakis, Panagiotis
Bagratuni, Tina
Mavropoulos-Papoudas, Stylianos
Roussou, Maria
Kastritis, Efstathios
Moulopoulos, Lia A.
Dimopoulos, Meletios A.
Terpos, Evangelos
Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title_full Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title_fullStr Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title_full_unstemmed Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title_short Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
title_sort newly diagnosed multiple myeloma patients with skeletal-related events and abnormal mri pattern have poor survival outcomes: a prospective study on 370 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181401/
https://www.ncbi.nlm.nih.gov/pubmed/35683473
http://dx.doi.org/10.3390/jcm11113088
work_keys_str_mv AT kanelliasnikolaos newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT ntanasisstathopoulosioannis newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT gavriatopouloumaria newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT koutoulidisvassilis newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT fotioudespina newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT migkoumagdalini newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT eleutherakispapaiakovouevangelos newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT malandrakispanagiotis newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT bagratunitina newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT mavropoulospapoudasstylianos newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT roussoumaria newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT kastritisefstathios newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT moulopoulosliaa newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT dimopoulosmeletiosa newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients
AT terposevangelos newlydiagnosedmultiplemyelomapatientswithskeletalrelatedeventsandabnormalmripatternhavepoorsurvivaloutcomesaprospectivestudyon370patients