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Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients
Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181401/ https://www.ncbi.nlm.nih.gov/pubmed/35683473 http://dx.doi.org/10.3390/jcm11113088 |
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author | Kanellias, Nikolaos Ntanasis-Stathopoulos, Ioannis Gavriatopoulou, Maria Koutoulidis, Vassilis Fotiou, Despina Migkou, Magdalini Eleutherakis-Papaiakovou, Evangelos Malandrakis, Panagiotis Bagratuni, Tina Mavropoulos-Papoudas, Stylianos Roussou, Maria Kastritis, Efstathios Moulopoulos, Lia A. Dimopoulos, Meletios A. Terpos, Evangelos |
author_facet | Kanellias, Nikolaos Ntanasis-Stathopoulos, Ioannis Gavriatopoulou, Maria Koutoulidis, Vassilis Fotiou, Despina Migkou, Magdalini Eleutherakis-Papaiakovou, Evangelos Malandrakis, Panagiotis Bagratuni, Tina Mavropoulos-Papoudas, Stylianos Roussou, Maria Kastritis, Efstathios Moulopoulos, Lia A. Dimopoulos, Meletios A. Terpos, Evangelos |
author_sort | Kanellias, Nikolaos |
collection | PubMed |
description | Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among newly diagnosed MMs (NDMM) and to explore the possible correlations with disease characteristics, imaging finding, and patient prognosis. A total of 370 patients with available baseline MRIs were included. Among them, 208 (56%) presented with at least one SRE at diagnosis. Fractures were the most common reported SREs (48%). The incidence of SREs at diagnosis was higher in patients with osteolytic lesions, abnormal MRI pattern, hypercalcemia, and at least 60% bone marrow infiltration by plasma cells. Importantly, the patients with normal MRI pattern, who did not present with SREs at diagnosis, had statistically significant improved median OS in comparison with the patients who had abnormal MRI patterns and/or the presence of SREs at diagnosis (9.3 vs. 6.6 years, p = 0.048). Our data, which represent one of a few systematic reports on the incidence and characteristics of SREs in the era of novel agents, was indicative of a high incidence of SREs at the time of MM diagnosis. Early detection of myeloma bone disease and tailored patient management are essential to optimize patient outcomes. |
format | Online Article Text |
id | pubmed-9181401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91814012022-06-10 Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients Kanellias, Nikolaos Ntanasis-Stathopoulos, Ioannis Gavriatopoulou, Maria Koutoulidis, Vassilis Fotiou, Despina Migkou, Magdalini Eleutherakis-Papaiakovou, Evangelos Malandrakis, Panagiotis Bagratuni, Tina Mavropoulos-Papoudas, Stylianos Roussou, Maria Kastritis, Efstathios Moulopoulos, Lia A. Dimopoulos, Meletios A. Terpos, Evangelos J Clin Med Article Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among newly diagnosed MMs (NDMM) and to explore the possible correlations with disease characteristics, imaging finding, and patient prognosis. A total of 370 patients with available baseline MRIs were included. Among them, 208 (56%) presented with at least one SRE at diagnosis. Fractures were the most common reported SREs (48%). The incidence of SREs at diagnosis was higher in patients with osteolytic lesions, abnormal MRI pattern, hypercalcemia, and at least 60% bone marrow infiltration by plasma cells. Importantly, the patients with normal MRI pattern, who did not present with SREs at diagnosis, had statistically significant improved median OS in comparison with the patients who had abnormal MRI patterns and/or the presence of SREs at diagnosis (9.3 vs. 6.6 years, p = 0.048). Our data, which represent one of a few systematic reports on the incidence and characteristics of SREs in the era of novel agents, was indicative of a high incidence of SREs at the time of MM diagnosis. Early detection of myeloma bone disease and tailored patient management are essential to optimize patient outcomes. MDPI 2022-05-30 /pmc/articles/PMC9181401/ /pubmed/35683473 http://dx.doi.org/10.3390/jcm11113088 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanellias, Nikolaos Ntanasis-Stathopoulos, Ioannis Gavriatopoulou, Maria Koutoulidis, Vassilis Fotiou, Despina Migkou, Magdalini Eleutherakis-Papaiakovou, Evangelos Malandrakis, Panagiotis Bagratuni, Tina Mavropoulos-Papoudas, Stylianos Roussou, Maria Kastritis, Efstathios Moulopoulos, Lia A. Dimopoulos, Meletios A. Terpos, Evangelos Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title | Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title_full | Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title_fullStr | Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title_full_unstemmed | Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title_short | Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients |
title_sort | newly diagnosed multiple myeloma patients with skeletal-related events and abnormal mri pattern have poor survival outcomes: a prospective study on 370 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181401/ https://www.ncbi.nlm.nih.gov/pubmed/35683473 http://dx.doi.org/10.3390/jcm11113088 |
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