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Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI)
Coronary reperfusion strategies are life-saving approaches to restore blood flow to cardiac tissue after acute myocardial infarction (AMI). However, the sudden restoration of normal blood flow leads to ischemia and reperfusion injury (IRI), which results in cardiomyoblast death, irreversible tissue...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181429/ https://www.ncbi.nlm.nih.gov/pubmed/35682772 http://dx.doi.org/10.3390/ijms23116090 |
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author | Piccoli, Marco Coviello, Simona Canali, Maria Elena Rota, Paola La Rocca, Paolo Cirillo, Federica Lavota, Ivana Tarantino, Adriana Ciconte, Giuseppe Pappone, Carlo Ghiroldi, Andrea Anastasia, Luigi |
author_facet | Piccoli, Marco Coviello, Simona Canali, Maria Elena Rota, Paola La Rocca, Paolo Cirillo, Federica Lavota, Ivana Tarantino, Adriana Ciconte, Giuseppe Pappone, Carlo Ghiroldi, Andrea Anastasia, Luigi |
author_sort | Piccoli, Marco |
collection | PubMed |
description | Coronary reperfusion strategies are life-saving approaches to restore blood flow to cardiac tissue after acute myocardial infarction (AMI). However, the sudden restoration of normal blood flow leads to ischemia and reperfusion injury (IRI), which results in cardiomyoblast death, irreversible tissue degeneration, and heart failure. The molecular mechanism of IRI is not fully understood, and there are no effective cardioprotective strategies to prevent it. In this study, we show that activation of sialidase-3, a glycohydrolytic enzyme that cleaves sialic acid residues from glycoconjugates, is cardioprotective by triggering RISK pro-survival signaling pathways. We found that overexpression of Neu3 significantly increased cardiomyoblast resistance to IRI through activation of HIF-1α and Akt/Erk signaling pathways. This raises the possibility of using Sialidase-3 activation as a cardioprotective reperfusion strategy after myocardial infarction. |
format | Online Article Text |
id | pubmed-9181429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91814292022-06-10 Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) Piccoli, Marco Coviello, Simona Canali, Maria Elena Rota, Paola La Rocca, Paolo Cirillo, Federica Lavota, Ivana Tarantino, Adriana Ciconte, Giuseppe Pappone, Carlo Ghiroldi, Andrea Anastasia, Luigi Int J Mol Sci Article Coronary reperfusion strategies are life-saving approaches to restore blood flow to cardiac tissue after acute myocardial infarction (AMI). However, the sudden restoration of normal blood flow leads to ischemia and reperfusion injury (IRI), which results in cardiomyoblast death, irreversible tissue degeneration, and heart failure. The molecular mechanism of IRI is not fully understood, and there are no effective cardioprotective strategies to prevent it. In this study, we show that activation of sialidase-3, a glycohydrolytic enzyme that cleaves sialic acid residues from glycoconjugates, is cardioprotective by triggering RISK pro-survival signaling pathways. We found that overexpression of Neu3 significantly increased cardiomyoblast resistance to IRI through activation of HIF-1α and Akt/Erk signaling pathways. This raises the possibility of using Sialidase-3 activation as a cardioprotective reperfusion strategy after myocardial infarction. MDPI 2022-05-29 /pmc/articles/PMC9181429/ /pubmed/35682772 http://dx.doi.org/10.3390/ijms23116090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Piccoli, Marco Coviello, Simona Canali, Maria Elena Rota, Paola La Rocca, Paolo Cirillo, Federica Lavota, Ivana Tarantino, Adriana Ciconte, Giuseppe Pappone, Carlo Ghiroldi, Andrea Anastasia, Luigi Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title | Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title_full | Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title_fullStr | Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title_full_unstemmed | Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title_short | Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) |
title_sort | neu3 sialidase activates the risk cardioprotective signaling pathway during ischemia and reperfusion injury (iri) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181429/ https://www.ncbi.nlm.nih.gov/pubmed/35682772 http://dx.doi.org/10.3390/ijms23116090 |
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