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Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge
CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had bee...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181498/ https://www.ncbi.nlm.nih.gov/pubmed/35682743 http://dx.doi.org/10.3390/ijms23116064 |
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author | Effendi, Wiwin Is Nagano, Tatsuya |
author_facet | Effendi, Wiwin Is Nagano, Tatsuya |
author_sort | Effendi, Wiwin Is |
collection | PubMed |
description | CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF. |
format | Online Article Text |
id | pubmed-9181498 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91814982022-06-10 Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge Effendi, Wiwin Is Nagano, Tatsuya Int J Mol Sci Review CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies confirmed that aberrant cellular senescence-associated mitochondria dysfunction and metabolic reprogramming had been identified in different IPF lung cells (alveolar epithelial cells, alveolar endothelial cells, fibroblasts, and macrophages). Here, we reviewed the role of the CTGF in IPF lung cells to mediate anomalous senescence-related metabolic mechanisms that support the fibrotic environment in IPF. MDPI 2022-05-28 /pmc/articles/PMC9181498/ /pubmed/35682743 http://dx.doi.org/10.3390/ijms23116064 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Effendi, Wiwin Is Nagano, Tatsuya Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title_full | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title_fullStr | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title_full_unstemmed | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title_short | Connective Tissue Growth Factor in Idiopathic Pulmonary Fibrosis: Breaking the Bridge |
title_sort | connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the bridge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181498/ https://www.ncbi.nlm.nih.gov/pubmed/35682743 http://dx.doi.org/10.3390/ijms23116064 |
work_keys_str_mv | AT effendiwiwinis connectivetissuegrowthfactorinidiopathicpulmonaryfibrosisbreakingthebridge AT naganotatsuya connectivetissuegrowthfactorinidiopathicpulmonaryfibrosisbreakingthebridge |