A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane

We reconstitute a phosphotyrosine-mediated protein condensation phase transition of the ∼200 residue cytoplasmic tail of the epidermal growth factor receptor (EGFR) and the adaptor protein, Grb2, on a membrane surface. The phase transition depends on phosphorylation of the EGFR tail, which recruits...

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Detalles Bibliográficos
Autores principales: Lin, Chun-Wei, Nocka, Laura M., Stinger, Brittany L., DeGrandchamp, Joseph B., Lew, L. J. Nugent, Alvarez, Steven, Phan, Henry T., Kondo, Yasushi, Kuriyan, John, Groves, Jay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181613/
https://www.ncbi.nlm.nih.gov/pubmed/35507881
http://dx.doi.org/10.1073/pnas.2122531119

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