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Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls

Neuropathic pain affects more than one million people across the globe. The quality of life of people suffering from neuropathic pain has been considerably declining due to the unavailability of appropriate therapeutics. Currently, available treatment options can only treat patients symptomatically,...

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Autores principales: Shinu, Pottathil, Morsy, Mohamed A., Nair, Anroop B., Mouslem, Abdulaziz K. Al, Venugopala, Katharigatta N., Goyal, Manoj, Bansal, Monika, Jacob, Shery, Deb, Pran Kishore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181614/
https://www.ncbi.nlm.nih.gov/pubmed/35683390
http://dx.doi.org/10.3390/jcm11113002
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author Shinu, Pottathil
Morsy, Mohamed A.
Nair, Anroop B.
Mouslem, Abdulaziz K. Al
Venugopala, Katharigatta N.
Goyal, Manoj
Bansal, Monika
Jacob, Shery
Deb, Pran Kishore
author_facet Shinu, Pottathil
Morsy, Mohamed A.
Nair, Anroop B.
Mouslem, Abdulaziz K. Al
Venugopala, Katharigatta N.
Goyal, Manoj
Bansal, Monika
Jacob, Shery
Deb, Pran Kishore
author_sort Shinu, Pottathil
collection PubMed
description Neuropathic pain affects more than one million people across the globe. The quality of life of people suffering from neuropathic pain has been considerably declining due to the unavailability of appropriate therapeutics. Currently, available treatment options can only treat patients symptomatically, but they are associated with severe adverse side effects and the development of tolerance over prolonged use. In the past decade, researchers were able to gain a better understanding of the mechanisms involved in neuropathic pain; thus, continuous efforts are evident, aiming to develop novel interventions with better efficacy instead of symptomatic treatment. The current review discusses the latest interventional strategies used in the treatment and management of neuropathic pain. This review also provides insights into the present scenario of pain research, particularly various interventional techniques such as spinal cord stimulation, steroid injection, neural blockade, transcranial/epidural stimulation, deep brain stimulation, percutaneous electrical nerve stimulation, neuroablative procedures, opto/chemogenetics, gene therapy, etc. In a nutshell, most of the above techniques are at preclinical stage and facing difficulty in translation to clinical studies due to the non-availability of appropriate methodologies. Therefore, continuing research on these interventional strategies may help in the development of promising novel therapies that can improve the quality of life of patients suffering from neuropathic pain.
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spelling pubmed-91816142022-06-10 Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls Shinu, Pottathil Morsy, Mohamed A. Nair, Anroop B. Mouslem, Abdulaziz K. Al Venugopala, Katharigatta N. Goyal, Manoj Bansal, Monika Jacob, Shery Deb, Pran Kishore J Clin Med Review Neuropathic pain affects more than one million people across the globe. The quality of life of people suffering from neuropathic pain has been considerably declining due to the unavailability of appropriate therapeutics. Currently, available treatment options can only treat patients symptomatically, but they are associated with severe adverse side effects and the development of tolerance over prolonged use. In the past decade, researchers were able to gain a better understanding of the mechanisms involved in neuropathic pain; thus, continuous efforts are evident, aiming to develop novel interventions with better efficacy instead of symptomatic treatment. The current review discusses the latest interventional strategies used in the treatment and management of neuropathic pain. This review also provides insights into the present scenario of pain research, particularly various interventional techniques such as spinal cord stimulation, steroid injection, neural blockade, transcranial/epidural stimulation, deep brain stimulation, percutaneous electrical nerve stimulation, neuroablative procedures, opto/chemogenetics, gene therapy, etc. In a nutshell, most of the above techniques are at preclinical stage and facing difficulty in translation to clinical studies due to the non-availability of appropriate methodologies. Therefore, continuing research on these interventional strategies may help in the development of promising novel therapies that can improve the quality of life of patients suffering from neuropathic pain. MDPI 2022-05-26 /pmc/articles/PMC9181614/ /pubmed/35683390 http://dx.doi.org/10.3390/jcm11113002 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shinu, Pottathil
Morsy, Mohamed A.
Nair, Anroop B.
Mouslem, Abdulaziz K. Al
Venugopala, Katharigatta N.
Goyal, Manoj
Bansal, Monika
Jacob, Shery
Deb, Pran Kishore
Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title_full Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title_fullStr Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title_full_unstemmed Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title_short Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls
title_sort novel therapies for the treatment of neuropathic pain: potential and pitfalls
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181614/
https://www.ncbi.nlm.nih.gov/pubmed/35683390
http://dx.doi.org/10.3390/jcm11113002
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