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COVID-19 and first manic episodes: a systematic review

Sars-CoV-2 is a respiratory virus that can access the central nervous system, as indicated by the presence of the virus in patients’ cerebrospinal fluid and the occurrence of several neurological syndromes during and after COVID-19. Growing evidence indicates that Sars-CoV-2 can also trigger the acu...

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Autores principales: Russo, Mirella, Calisi, Dario, De Rosa, Matteo A., Evangelista, Giacomo, Consoli, Stefano, Dono, Fedele, Santilli, Matteo, Gambi, Francesco, Onofrj, Marco, Di Giannantonio, Massimo, Parruti, Giustino, Sensi, Stefano L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181635/
https://www.ncbi.nlm.nih.gov/pubmed/35716481
http://dx.doi.org/10.1016/j.psychres.2022.114677
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author Russo, Mirella
Calisi, Dario
De Rosa, Matteo A.
Evangelista, Giacomo
Consoli, Stefano
Dono, Fedele
Santilli, Matteo
Gambi, Francesco
Onofrj, Marco
Di Giannantonio, Massimo
Parruti, Giustino
Sensi, Stefano L.
author_facet Russo, Mirella
Calisi, Dario
De Rosa, Matteo A.
Evangelista, Giacomo
Consoli, Stefano
Dono, Fedele
Santilli, Matteo
Gambi, Francesco
Onofrj, Marco
Di Giannantonio, Massimo
Parruti, Giustino
Sensi, Stefano L.
author_sort Russo, Mirella
collection PubMed
description Sars-CoV-2 is a respiratory virus that can access the central nervous system, as indicated by the presence of the virus in patients’ cerebrospinal fluid and the occurrence of several neurological syndromes during and after COVID-19. Growing evidence indicates that Sars-CoV-2 can also trigger the acute onset of mood disorders or psychotic symptoms. COVID-19-related first episodes of mania, in subjects with no known history of bipolar disorder, have never been systematically analyzed. Thus, the present study assesses a potential link between the two conditions. This systematic review analyzes cases of first appearance of manic episodes associated with COVID-19. Clinical features, pharmacological therapies, and relationships with pre-existing medical conditions are also appraised. Medical records of twenty-three patients fulfilling the current DSM-5 criteria for manic episode were included. Manic episodes started, on average, after 12.71±6.65 days from the infection onset. Psychotic symptoms were frequently reported. 82.61% of patients exhibited delusions, whereas 39.13% of patients presented hallucinations. A large discrepancy in the diagnostic workups was observed. Mania represents an underestimated clinical presentation of COVID-19. Further studies should focus on the pathophysiological substrates of COVID-19-related mania and pursue appropriate and specific diagnostic and therapeutic workups.
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spelling pubmed-91816352022-06-10 COVID-19 and first manic episodes: a systematic review Russo, Mirella Calisi, Dario De Rosa, Matteo A. Evangelista, Giacomo Consoli, Stefano Dono, Fedele Santilli, Matteo Gambi, Francesco Onofrj, Marco Di Giannantonio, Massimo Parruti, Giustino Sensi, Stefano L. Psychiatry Res Review Article Sars-CoV-2 is a respiratory virus that can access the central nervous system, as indicated by the presence of the virus in patients’ cerebrospinal fluid and the occurrence of several neurological syndromes during and after COVID-19. Growing evidence indicates that Sars-CoV-2 can also trigger the acute onset of mood disorders or psychotic symptoms. COVID-19-related first episodes of mania, in subjects with no known history of bipolar disorder, have never been systematically analyzed. Thus, the present study assesses a potential link between the two conditions. This systematic review analyzes cases of first appearance of manic episodes associated with COVID-19. Clinical features, pharmacological therapies, and relationships with pre-existing medical conditions are also appraised. Medical records of twenty-three patients fulfilling the current DSM-5 criteria for manic episode were included. Manic episodes started, on average, after 12.71±6.65 days from the infection onset. Psychotic symptoms were frequently reported. 82.61% of patients exhibited delusions, whereas 39.13% of patients presented hallucinations. A large discrepancy in the diagnostic workups was observed. Mania represents an underestimated clinical presentation of COVID-19. Further studies should focus on the pathophysiological substrates of COVID-19-related mania and pursue appropriate and specific diagnostic and therapeutic workups. Elsevier B.V. 2022-08 2022-06-09 /pmc/articles/PMC9181635/ /pubmed/35716481 http://dx.doi.org/10.1016/j.psychres.2022.114677 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Russo, Mirella
Calisi, Dario
De Rosa, Matteo A.
Evangelista, Giacomo
Consoli, Stefano
Dono, Fedele
Santilli, Matteo
Gambi, Francesco
Onofrj, Marco
Di Giannantonio, Massimo
Parruti, Giustino
Sensi, Stefano L.
COVID-19 and first manic episodes: a systematic review
title COVID-19 and first manic episodes: a systematic review
title_full COVID-19 and first manic episodes: a systematic review
title_fullStr COVID-19 and first manic episodes: a systematic review
title_full_unstemmed COVID-19 and first manic episodes: a systematic review
title_short COVID-19 and first manic episodes: a systematic review
title_sort covid-19 and first manic episodes: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181635/
https://www.ncbi.nlm.nih.gov/pubmed/35716481
http://dx.doi.org/10.1016/j.psychres.2022.114677
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