Cargando…
Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors
In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), and AngioTool and Erlangen-Angio-Tool (EA-To...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181641/ https://www.ncbi.nlm.nih.gov/pubmed/35683633 http://dx.doi.org/10.3390/jcm11113248 |
_version_ | 1784723826574098432 |
---|---|
author | López-Cuenca, Inés Salobrar-García, Elena Sánchez-Puebla, Lidia Espejel, Eva García del Arco, Lucía Rojas, Pilar Elvira-Hurtado, Lorena Fernández-Albarral, José A. Ramírez-Toraño, Federico Barabash, Ana Salazar, Juan J. Ramírez, José M. de Hoz, Rosa Ramírez, Ana I. |
author_facet | López-Cuenca, Inés Salobrar-García, Elena Sánchez-Puebla, Lidia Espejel, Eva García del Arco, Lucía Rojas, Pilar Elvira-Hurtado, Lorena Fernández-Albarral, José A. Ramírez-Toraño, Federico Barabash, Ana Salazar, Juan J. Ramírez, José M. de Hoz, Rosa Ramírez, Ana I. |
author_sort | López-Cuenca, Inés |
collection | PubMed |
description | In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), and AngioTool and Erlangen-Angio-Tool (EA-Tool) as imaging analysis software. Retinal vascularization was analyzed by measuring hypercholesterolemia (HCL) and high blood pressure (HBP). Angio-Tool showed a statistically significant higher percentage of area occupied by vessels in the FH+ ApoE ɛ4- group vs. in the FH+ ApoE ɛ4+ group, and EA-Tool showed statistically significant higher vascular densities in the C3 ring in the FH+ ApoE ɛ4+ group when compared with: i)FH- ApoE ɛ4- in sectors H3, H4, H10 and H11; and ii) FH+ ApoE ɛ4- in sectors H4 and H12. In participants with HCL and HBP, statistically significant changes were found, in particular using EA-Tool, both in the macular area, mainly in the deep plexus, and in the peripapillary area. In conclusion, OCTA in subjects with genetic risk factors for the development of AD showed an apparent increase in vascular density in some sectors of the retina, which was one of the first vascular changes detectable. These changes constitute a promising biomarker for monitoring the progression of pathological neuronal degeneration. |
format | Online Article Text |
id | pubmed-9181641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91816412022-06-10 Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors López-Cuenca, Inés Salobrar-García, Elena Sánchez-Puebla, Lidia Espejel, Eva García del Arco, Lucía Rojas, Pilar Elvira-Hurtado, Lorena Fernández-Albarral, José A. Ramírez-Toraño, Federico Barabash, Ana Salazar, Juan J. Ramírez, José M. de Hoz, Rosa Ramírez, Ana I. J Clin Med Article In 103 subjects with a high genetic risk of developing Alzheimer’s disease (AD), family history (FH) of AD and ApoE ɛ4 characterization (ApoE ɛ4) were analyzed for changes in the retinal vascular network by OCTA (optical coherence tomography angiography), and AngioTool and Erlangen-Angio-Tool (EA-Tool) as imaging analysis software. Retinal vascularization was analyzed by measuring hypercholesterolemia (HCL) and high blood pressure (HBP). Angio-Tool showed a statistically significant higher percentage of area occupied by vessels in the FH+ ApoE ɛ4- group vs. in the FH+ ApoE ɛ4+ group, and EA-Tool showed statistically significant higher vascular densities in the C3 ring in the FH+ ApoE ɛ4+ group when compared with: i)FH- ApoE ɛ4- in sectors H3, H4, H10 and H11; and ii) FH+ ApoE ɛ4- in sectors H4 and H12. In participants with HCL and HBP, statistically significant changes were found, in particular using EA-Tool, both in the macular area, mainly in the deep plexus, and in the peripapillary area. In conclusion, OCTA in subjects with genetic risk factors for the development of AD showed an apparent increase in vascular density in some sectors of the retina, which was one of the first vascular changes detectable. These changes constitute a promising biomarker for monitoring the progression of pathological neuronal degeneration. MDPI 2022-06-06 /pmc/articles/PMC9181641/ /pubmed/35683633 http://dx.doi.org/10.3390/jcm11113248 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article López-Cuenca, Inés Salobrar-García, Elena Sánchez-Puebla, Lidia Espejel, Eva García del Arco, Lucía Rojas, Pilar Elvira-Hurtado, Lorena Fernández-Albarral, José A. Ramírez-Toraño, Federico Barabash, Ana Salazar, Juan J. Ramírez, José M. de Hoz, Rosa Ramírez, Ana I. Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title | Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title_full | Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title_fullStr | Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title_full_unstemmed | Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title_short | Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer’s Disease and Cardiovascular Risk Factors |
title_sort | retinal vascular study using octa in subjects at high genetic risk of developing alzheimer’s disease and cardiovascular risk factors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181641/ https://www.ncbi.nlm.nih.gov/pubmed/35683633 http://dx.doi.org/10.3390/jcm11113248 |
work_keys_str_mv | AT lopezcuencaines retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT salobrargarciaelena retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT sanchezpueblalidia retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT espejeleva retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT garciadelarcolucia retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT rojaspilar retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT elvirahurtadolorena retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT fernandezalbarraljosea retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT ramireztoranofederico retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT barabashana retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT salazarjuanj retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT ramirezjosem retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT dehozrosa retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors AT ramirezanai retinalvascularstudyusingoctainsubjectsathighgeneticriskofdevelopingalzheimersdiseaseandcardiovascularriskfactors |