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Animal Models and Helicobacter pylori Infection
Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181647/ https://www.ncbi.nlm.nih.gov/pubmed/35683528 http://dx.doi.org/10.3390/jcm11113141 |
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author | Ansari, Shamshul Yamaoka, Yoshio |
author_facet | Ansari, Shamshul Yamaoka, Yoshio |
author_sort | Ansari, Shamshul |
collection | PubMed |
description | Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models. |
format | Online Article Text |
id | pubmed-9181647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91816472022-06-10 Animal Models and Helicobacter pylori Infection Ansari, Shamshul Yamaoka, Yoshio J Clin Med Review Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models. MDPI 2022-05-31 /pmc/articles/PMC9181647/ /pubmed/35683528 http://dx.doi.org/10.3390/jcm11113141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ansari, Shamshul Yamaoka, Yoshio Animal Models and Helicobacter pylori Infection |
title | Animal Models and Helicobacter pylori Infection |
title_full | Animal Models and Helicobacter pylori Infection |
title_fullStr | Animal Models and Helicobacter pylori Infection |
title_full_unstemmed | Animal Models and Helicobacter pylori Infection |
title_short | Animal Models and Helicobacter pylori Infection |
title_sort | animal models and helicobacter pylori infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181647/ https://www.ncbi.nlm.nih.gov/pubmed/35683528 http://dx.doi.org/10.3390/jcm11113141 |
work_keys_str_mv | AT ansarishamshul animalmodelsandhelicobacterpyloriinfection AT yamaokayoshio animalmodelsandhelicobacterpyloriinfection |