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Animal Models and Helicobacter pylori Infection

Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studi...

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Detalles Bibliográficos
Autores principales: Ansari, Shamshul, Yamaoka, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181647/
https://www.ncbi.nlm.nih.gov/pubmed/35683528
http://dx.doi.org/10.3390/jcm11113141
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author Ansari, Shamshul
Yamaoka, Yoshio
author_facet Ansari, Shamshul
Yamaoka, Yoshio
author_sort Ansari, Shamshul
collection PubMed
description Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models.
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spelling pubmed-91816472022-06-10 Animal Models and Helicobacter pylori Infection Ansari, Shamshul Yamaoka, Yoshio J Clin Med Review Helicobacter pylori colonize the gastric mucosa of at least half of the world’s population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models. MDPI 2022-05-31 /pmc/articles/PMC9181647/ /pubmed/35683528 http://dx.doi.org/10.3390/jcm11113141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ansari, Shamshul
Yamaoka, Yoshio
Animal Models and Helicobacter pylori Infection
title Animal Models and Helicobacter pylori Infection
title_full Animal Models and Helicobacter pylori Infection
title_fullStr Animal Models and Helicobacter pylori Infection
title_full_unstemmed Animal Models and Helicobacter pylori Infection
title_short Animal Models and Helicobacter pylori Infection
title_sort animal models and helicobacter pylori infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181647/
https://www.ncbi.nlm.nih.gov/pubmed/35683528
http://dx.doi.org/10.3390/jcm11113141
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