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Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance
Notch signaling dysregulation encourages breast cancer progression through different mechanisms such as stem cell maintenance, cell proliferation and migration/invasion. Furthermore, Notch is a crucial driver regulating juxtracrine and paracrine communications between tumor and stroma. The complex i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181656/ https://www.ncbi.nlm.nih.gov/pubmed/35682974 http://dx.doi.org/10.3390/ijms23116296 |
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author | Chimento, Adele D’Amico, Maria Pezzi, Vincenzo De Amicis, Francesca |
author_facet | Chimento, Adele D’Amico, Maria Pezzi, Vincenzo De Amicis, Francesca |
author_sort | Chimento, Adele |
collection | PubMed |
description | Notch signaling dysregulation encourages breast cancer progression through different mechanisms such as stem cell maintenance, cell proliferation and migration/invasion. Furthermore, Notch is a crucial driver regulating juxtracrine and paracrine communications between tumor and stroma. The complex interplay between the abnormal Notch pathway orchestrating the activation of other signals and cellular heterogeneity contribute towards remodeling of the tumor microenvironment. These changes, together with tumor evolution and treatment pressure, drive breast cancer drug resistance. Preclinical studies have shown that targeting the Notch pathway can prevent or reverse resistance, reducing or eliminating breast cancer stem cells. In the present review, we will summarize the current scientific evidence that highlights the involvement of Notch activation within the breast tumor microenvironment, angiogenesis, extracellular matrix remodeling, and tumor/stroma/immune system interplay and its involvement in mechanisms of therapy resistance. |
format | Online Article Text |
id | pubmed-9181656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91816562022-06-10 Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance Chimento, Adele D’Amico, Maria Pezzi, Vincenzo De Amicis, Francesca Int J Mol Sci Review Notch signaling dysregulation encourages breast cancer progression through different mechanisms such as stem cell maintenance, cell proliferation and migration/invasion. Furthermore, Notch is a crucial driver regulating juxtracrine and paracrine communications between tumor and stroma. The complex interplay between the abnormal Notch pathway orchestrating the activation of other signals and cellular heterogeneity contribute towards remodeling of the tumor microenvironment. These changes, together with tumor evolution and treatment pressure, drive breast cancer drug resistance. Preclinical studies have shown that targeting the Notch pathway can prevent or reverse resistance, reducing or eliminating breast cancer stem cells. In the present review, we will summarize the current scientific evidence that highlights the involvement of Notch activation within the breast tumor microenvironment, angiogenesis, extracellular matrix remodeling, and tumor/stroma/immune system interplay and its involvement in mechanisms of therapy resistance. MDPI 2022-06-04 /pmc/articles/PMC9181656/ /pubmed/35682974 http://dx.doi.org/10.3390/ijms23116296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chimento, Adele D’Amico, Maria Pezzi, Vincenzo De Amicis, Francesca Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title | Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title_full | Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title_fullStr | Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title_full_unstemmed | Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title_short | Notch Signaling in Breast Tumor Microenvironment as Mediator of Drug Resistance |
title_sort | notch signaling in breast tumor microenvironment as mediator of drug resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181656/ https://www.ncbi.nlm.nih.gov/pubmed/35682974 http://dx.doi.org/10.3390/ijms23116296 |
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