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Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity

Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of the liver, and data on patient outcome after surgical treatment are scarce. The aim of this study was to evaluate postoperative morbidity and overall survival (OS) of patients who underwent hepatectomy for PHA. This is a bicentric retro...

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Autores principales: Katou, Shadi, Di Pietro Martinelli, Claudine, Silveira, Carolina, Schmid, Franziska, Becker, Felix, Radunz, Sonia, Juratli, Mazen, Morgul, Haluk, Banz, Vanessa, Pascher, Andreas, Andreou, Andreas, Struecker, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181818/
https://www.ncbi.nlm.nih.gov/pubmed/35683376
http://dx.doi.org/10.3390/jcm11112990
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author Katou, Shadi
Di Pietro Martinelli, Claudine
Silveira, Carolina
Schmid, Franziska
Becker, Felix
Radunz, Sonia
Juratli, Mazen
Morgul, Haluk
Banz, Vanessa
Pascher, Andreas
Andreou, Andreas
Struecker, Benjamin
author_facet Katou, Shadi
Di Pietro Martinelli, Claudine
Silveira, Carolina
Schmid, Franziska
Becker, Felix
Radunz, Sonia
Juratli, Mazen
Morgul, Haluk
Banz, Vanessa
Pascher, Andreas
Andreou, Andreas
Struecker, Benjamin
author_sort Katou, Shadi
collection PubMed
description Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of the liver, and data on patient outcome after surgical treatment are scarce. The aim of this study was to evaluate postoperative morbidity and overall survival (OS) of patients who underwent hepatectomy for PHA. This is a bicentric retrospective analysis of all consecutive patients who underwent liver resection in curative intent for PHA between 2012 and 2019 at the University Hospital of Muenster and the University Hospital of Bern. Nine patients (five female, four male) were included from both centers. Median age was 72 years (44–82). Most lesions (77.8%) were larger than 5 cm, and mean size of the biggest lesion was 9.4 ± 4.5 cm. Major hepatectomy was performed in four (44.4%), and radical resection (R0) was achieved in six (66.7%) patients. Postoperative complication rate was 88.8%, including 44.4% higher than 3a in the Clavien–Dindo classification. OS survival rates at 1, 2, and 3 years were 44.4%, 22.2%, and 12.5%, respectively, and median OS was 5 months. OS was significantly better after radical resection (R0: 15 months vs. R1: 0 months, p = 0.04), whereas presentation with tumor rupture at diagnosis was associated with the worst OS (0 months vs. 15 months, p = 0.005). Disease recurrence occurred in three patients (33.3%) between three and seven months after surgery. Radical resection remains the only potentially curative treatment option for PHA. However, postoperative morbidity is high, and the overall prognosis remains poor. Multimodal therapy options and management strategies are urgently needed and could improve the prognosis of patients suffering from PHA in the future.
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spelling pubmed-91818182022-06-10 Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity Katou, Shadi Di Pietro Martinelli, Claudine Silveira, Carolina Schmid, Franziska Becker, Felix Radunz, Sonia Juratli, Mazen Morgul, Haluk Banz, Vanessa Pascher, Andreas Andreou, Andreas Struecker, Benjamin J Clin Med Article Primary hepatic angiosarcoma (PHA) is a rare malignant tumor of the liver, and data on patient outcome after surgical treatment are scarce. The aim of this study was to evaluate postoperative morbidity and overall survival (OS) of patients who underwent hepatectomy for PHA. This is a bicentric retrospective analysis of all consecutive patients who underwent liver resection in curative intent for PHA between 2012 and 2019 at the University Hospital of Muenster and the University Hospital of Bern. Nine patients (five female, four male) were included from both centers. Median age was 72 years (44–82). Most lesions (77.8%) were larger than 5 cm, and mean size of the biggest lesion was 9.4 ± 4.5 cm. Major hepatectomy was performed in four (44.4%), and radical resection (R0) was achieved in six (66.7%) patients. Postoperative complication rate was 88.8%, including 44.4% higher than 3a in the Clavien–Dindo classification. OS survival rates at 1, 2, and 3 years were 44.4%, 22.2%, and 12.5%, respectively, and median OS was 5 months. OS was significantly better after radical resection (R0: 15 months vs. R1: 0 months, p = 0.04), whereas presentation with tumor rupture at diagnosis was associated with the worst OS (0 months vs. 15 months, p = 0.005). Disease recurrence occurred in three patients (33.3%) between three and seven months after surgery. Radical resection remains the only potentially curative treatment option for PHA. However, postoperative morbidity is high, and the overall prognosis remains poor. Multimodal therapy options and management strategies are urgently needed and could improve the prognosis of patients suffering from PHA in the future. MDPI 2022-05-25 /pmc/articles/PMC9181818/ /pubmed/35683376 http://dx.doi.org/10.3390/jcm11112990 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Katou, Shadi
Di Pietro Martinelli, Claudine
Silveira, Carolina
Schmid, Franziska
Becker, Felix
Radunz, Sonia
Juratli, Mazen
Morgul, Haluk
Banz, Vanessa
Pascher, Andreas
Andreou, Andreas
Struecker, Benjamin
Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title_full Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title_fullStr Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title_full_unstemmed Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title_short Liver Resection for Primary Hepatic Angiosarcoma: Bicentric Analysis of a Challenging Entity
title_sort liver resection for primary hepatic angiosarcoma: bicentric analysis of a challenging entity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181818/
https://www.ncbi.nlm.nih.gov/pubmed/35683376
http://dx.doi.org/10.3390/jcm11112990
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