New Coordination Compounds Based on a Pyrazine Derivative: Design, Characterization, and Biological Study

New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N′-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques: elemental analysis (EA), thermogravimetric analysis (TG–DTG), infrared spectro...

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Detalles Bibliográficos
Autores principales: Climova, Alina, Pivovarova, Ekaterina, Rogalewicz, Bartłomiej, Raducka, Anita, Szczesio, Małgorzata, Korona-Głowniak, Izabela, Korga-Plewko, Agnieszka, Iwan, Magdalena, Gobis, Katarzyna, Czylkowska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181841/
https://www.ncbi.nlm.nih.gov/pubmed/35684404
http://dx.doi.org/10.3390/molecules27113467
Descripción
Sumario:New coordination compounds of Mn(II), Fe(III), Co(II), and Ni(II) and the biologically active ligand L (N′-benzylidenepyrazine-2-carbohydrazonamide) were synthesized and characterized by appropriate analytical techniques: elemental analysis (EA), thermogravimetric analysis (TG–DTG), infrared spectroscopy (FTIR), and flame-atomic absorption spectrometry (F-AAS). The biological activity of the obtained compounds was then comprehensively investigated. Rational use of these compounds as potential drugs was proven by ADME analysis. All obtained compounds were screened in vitro for antibacterial, antifungal, and anticancer activities. Some of the studied complexes exhibited significantly higher activity than the ligand alone.

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