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Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare

Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza(®), 1-Lekobaza(...

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Autores principales: Kroma, Anna, Pawlaczyk, Mariola, Feliczak-Guzik, Agnieszka, Urbańska, Maria, Jenerowicz, Dorota, Seraszek-Jaros, Agnieszka, Kikowska, Małgorzata, Gornowicz-Porowska, Justyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181847/
https://www.ncbi.nlm.nih.gov/pubmed/35684408
http://dx.doi.org/10.3390/molecules27113471
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author Kroma, Anna
Pawlaczyk, Mariola
Feliczak-Guzik, Agnieszka
Urbańska, Maria
Jenerowicz, Dorota
Seraszek-Jaros, Agnieszka
Kikowska, Małgorzata
Gornowicz-Porowska, Justyna
author_facet Kroma, Anna
Pawlaczyk, Mariola
Feliczak-Guzik, Agnieszka
Urbańska, Maria
Jenerowicz, Dorota
Seraszek-Jaros, Agnieszka
Kikowska, Małgorzata
Gornowicz-Porowska, Justyna
author_sort Kroma, Anna
collection PubMed
description Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza(®), 1-Lekobaza(®), S. coronata, 2-Lekobaza(®), Salicylic acid, 3-Lekobaza(®), S. coronata, Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0—none to 4—very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1–3 reduced scaling. Our study confirmed a beneficial effect of creams containing S. coronata extract on psoriatic lesions.
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spelling pubmed-91818472022-06-10 Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare Kroma, Anna Pawlaczyk, Mariola Feliczak-Guzik, Agnieszka Urbańska, Maria Jenerowicz, Dorota Seraszek-Jaros, Agnieszka Kikowska, Małgorzata Gornowicz-Porowska, Justyna Molecules Article Phytoecdysones from Serratula coronata seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of S. coronata on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza(®), 1-Lekobaza(®), S. coronata, 2-Lekobaza(®), Salicylic acid, 3-Lekobaza(®), S. coronata, Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0—none to 4—very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1–3 reduced scaling. Our study confirmed a beneficial effect of creams containing S. coronata extract on psoriatic lesions. MDPI 2022-05-27 /pmc/articles/PMC9181847/ /pubmed/35684408 http://dx.doi.org/10.3390/molecules27113471 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kroma, Anna
Pawlaczyk, Mariola
Feliczak-Guzik, Agnieszka
Urbańska, Maria
Jenerowicz, Dorota
Seraszek-Jaros, Agnieszka
Kikowska, Małgorzata
Gornowicz-Porowska, Justyna
Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title_full Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title_fullStr Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title_full_unstemmed Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title_short Phytoecdysteroids from Serratula coronata L. for Psoriatic Skincare
title_sort phytoecdysteroids from serratula coronata l. for psoriatic skincare
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181847/
https://www.ncbi.nlm.nih.gov/pubmed/35684408
http://dx.doi.org/10.3390/molecules27113471
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