Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas

Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experi...

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Autores principales: He, Yi-Lin, Huang, Pei-Zhi, Yang, Hong-Ying, Feng, Wei-Jiao, Li, Zhao-Cai, Gao, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182123/
https://www.ncbi.nlm.nih.gov/pubmed/35684476
http://dx.doi.org/10.3390/molecules27113540
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author He, Yi-Lin
Huang, Pei-Zhi
Yang, Hong-Ying
Feng, Wei-Jiao
Li, Zhao-Cai
Gao, Kun
author_facet He, Yi-Lin
Huang, Pei-Zhi
Yang, Hong-Ying
Feng, Wei-Jiao
Li, Zhao-Cai
Gao, Kun
author_sort He, Yi-Lin
collection PubMed
description Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM.
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spelling pubmed-91821232022-06-10 Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas He, Yi-Lin Huang, Pei-Zhi Yang, Hong-Ying Feng, Wei-Jiao Li, Zhao-Cai Gao, Kun Molecules Article Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM. MDPI 2022-05-31 /pmc/articles/PMC9182123/ /pubmed/35684476 http://dx.doi.org/10.3390/molecules27113540 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
He, Yi-Lin
Huang, Pei-Zhi
Yang, Hong-Ying
Feng, Wei-Jiao
Li, Zhao-Cai
Gao, Kun
Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title_full Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title_fullStr Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title_full_unstemmed Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title_short Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
title_sort jatrolignans c and d: new neolignan epimers from jatropha curcas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182123/
https://www.ncbi.nlm.nih.gov/pubmed/35684476
http://dx.doi.org/10.3390/molecules27113540
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