Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments

An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and an...

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Autores principales: Mukusheva, Gulim K., Zhasymbekova, Aigerym R., Seidakhmetova, Roza B., Nurkenov, Oralgazy A., Akishina, Ekaterina A., Petkevich, Sergey K., Dikusar, Evgenij A., Potkin, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182173/
https://www.ncbi.nlm.nih.gov/pubmed/35684414
http://dx.doi.org/10.3390/molecules27113476
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author Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
author_facet Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
author_sort Mukusheva, Gulim K.
collection PubMed
description An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid.
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spelling pubmed-91821732022-06-10 Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments Mukusheva, Gulim K. Zhasymbekova, Aigerym R. Seidakhmetova, Roza B. Nurkenov, Oralgazy A. Akishina, Ekaterina A. Petkevich, Sergey K. Dikusar, Evgenij A. Potkin, Vladimir I. Molecules Article An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds were tested for antiviral, antimicrobial and analgesic activity. The most pronounced antibacterial activity was shown by the compounds 2e, 3b, 3c and 3e with isoxazole and pyridine fragments. It was found that most of the tested compounds showed significant analgesic activity reducing the pain response of animals to the irritating effect of acetic acid. MDPI 2022-05-27 /pmc/articles/PMC9182173/ /pubmed/35684414 http://dx.doi.org/10.3390/molecules27113476 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mukusheva, Gulim K.
Zhasymbekova, Aigerym R.
Seidakhmetova, Roza B.
Nurkenov, Oralgazy A.
Akishina, Ekaterina A.
Petkevich, Sergey K.
Dikusar, Evgenij A.
Potkin, Vladimir I.
Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title_full Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title_fullStr Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title_full_unstemmed Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title_short Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments
title_sort quinine esters with 1,2-azole, pyridine and adamantane fragments
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182173/
https://www.ncbi.nlm.nih.gov/pubmed/35684414
http://dx.doi.org/10.3390/molecules27113476
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