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Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses

Spearmint (Mentha spicata L.) has been widely studied for its diversity of compounds for product generation. However, studies describing the chemical and biological characteristics of commercial spearmint materials from different origins are scarce. For this reason, this research aimed to bioprospec...

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Autores principales: Henao-Rojas, Juan Camilo, Osorio, Edison, Isaza, Stephanie, Madronero-Solarte, Inés Amelia, Sierra, Karina, Zapata-Vahos, Isabel Cristina, Betancur-Pérez, Jhon Fredy, Arboleda-Valencia, Jorge W., Gallego, Adriana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182276/
https://www.ncbi.nlm.nih.gov/pubmed/35684496
http://dx.doi.org/10.3390/molecules27113559
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author Henao-Rojas, Juan Camilo
Osorio, Edison
Isaza, Stephanie
Madronero-Solarte, Inés Amelia
Sierra, Karina
Zapata-Vahos, Isabel Cristina
Betancur-Pérez, Jhon Fredy
Arboleda-Valencia, Jorge W.
Gallego, Adriana M.
author_facet Henao-Rojas, Juan Camilo
Osorio, Edison
Isaza, Stephanie
Madronero-Solarte, Inés Amelia
Sierra, Karina
Zapata-Vahos, Isabel Cristina
Betancur-Pérez, Jhon Fredy
Arboleda-Valencia, Jorge W.
Gallego, Adriana M.
author_sort Henao-Rojas, Juan Camilo
collection PubMed
description Spearmint (Mentha spicata L.) has been widely studied for its diversity of compounds for product generation. However, studies describing the chemical and biological characteristics of commercial spearmint materials from different origins are scarce. For this reason, this research aimed to bioprospecting spearmint from three origins: Colombia (Col), Mexico (Mex), and Egypt (Eg). We performed a biological activity analysis, such as FRAP, DPPH, and ABTS, inhibition potential of S. pyogenes, K. pneumoniae, E. coli, P. aeuroginosa, S. aureus, S aureus Methicillin-Resistant, and E. faecalis. Furthermore, we performed chemical assays, such as total polyphenol and rosmarinic acid, and untargeted metabolomics via HPLC-MS/MS. Finally, we developed a causality analysis to integrate biological activities with chemical analyses. We found significant differences between the samples for the total polyphenol and rosmarinic acid contents, FRAP, and inhibition analyses for Methicillin-Resistant S. aureus and E. faecalis. Also, clear metabolic differentiation was observed among the three commercial materials evaluated. These results allow us to propose data-driven uses for the three spearmint materials available in current markets.
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spelling pubmed-91822762022-06-10 Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses Henao-Rojas, Juan Camilo Osorio, Edison Isaza, Stephanie Madronero-Solarte, Inés Amelia Sierra, Karina Zapata-Vahos, Isabel Cristina Betancur-Pérez, Jhon Fredy Arboleda-Valencia, Jorge W. Gallego, Adriana M. Molecules Article Spearmint (Mentha spicata L.) has been widely studied for its diversity of compounds for product generation. However, studies describing the chemical and biological characteristics of commercial spearmint materials from different origins are scarce. For this reason, this research aimed to bioprospecting spearmint from three origins: Colombia (Col), Mexico (Mex), and Egypt (Eg). We performed a biological activity analysis, such as FRAP, DPPH, and ABTS, inhibition potential of S. pyogenes, K. pneumoniae, E. coli, P. aeuroginosa, S. aureus, S aureus Methicillin-Resistant, and E. faecalis. Furthermore, we performed chemical assays, such as total polyphenol and rosmarinic acid, and untargeted metabolomics via HPLC-MS/MS. Finally, we developed a causality analysis to integrate biological activities with chemical analyses. We found significant differences between the samples for the total polyphenol and rosmarinic acid contents, FRAP, and inhibition analyses for Methicillin-Resistant S. aureus and E. faecalis. Also, clear metabolic differentiation was observed among the three commercial materials evaluated. These results allow us to propose data-driven uses for the three spearmint materials available in current markets. MDPI 2022-05-31 /pmc/articles/PMC9182276/ /pubmed/35684496 http://dx.doi.org/10.3390/molecules27113559 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Henao-Rojas, Juan Camilo
Osorio, Edison
Isaza, Stephanie
Madronero-Solarte, Inés Amelia
Sierra, Karina
Zapata-Vahos, Isabel Cristina
Betancur-Pérez, Jhon Fredy
Arboleda-Valencia, Jorge W.
Gallego, Adriana M.
Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title_full Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title_fullStr Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title_full_unstemmed Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title_short Towards Bioprospection of Commercial Materials of Mentha spicata L. Using a Combined Strategy of Metabolomics and Biological Activity Analyses
title_sort towards bioprospection of commercial materials of mentha spicata l. using a combined strategy of metabolomics and biological activity analyses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182276/
https://www.ncbi.nlm.nih.gov/pubmed/35684496
http://dx.doi.org/10.3390/molecules27113559
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