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Haemagglutinin substitutions N125D, D127E, D222G and R223Q improve replicative fitness and vaccine effectiveness of an A/H1N1pdm09 live attenuated influenza vaccine virus by enhancing α-2,6 receptor binding

During 2013–14 and 2015–16, A/H1N1pdm09 live attenuated influenza vaccine (LAIV) viruses replicated inefficiently in primary human nasal epithelial cells (hNEC). This led to reduced vaccine effectiveness (VE) in quadrivalent formulations, mediated by inter-strain competition. By mutating the haemagg...

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Detalles Bibliográficos
Autores principales:	Dempsey, Rachael, Tamburrino, Giulia, Schewe, Katarzyna E., Crowe, Jonathan, Nuccitelli, Annalisa, Dibben, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182293/ https://www.ncbi.nlm.nih.gov/pubmed/35622874 http://dx.doi.org/10.1371/journal.ppat.1010585

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