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The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts

In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antio...

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Autores principales: Xiao, Luhua, Lu, Xiaoying, Yang, Huilin, Lin, Cuiqing, Li, Le, Ni, Chen, Fang, Yuan, Mo, Suifen, Zhan, Ruoting, Yan, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182326/
https://www.ncbi.nlm.nih.gov/pubmed/35684361
http://dx.doi.org/10.3390/molecules27113423
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author Xiao, Luhua
Lu, Xiaoying
Yang, Huilin
Lin, Cuiqing
Li, Le
Ni, Chen
Fang, Yuan
Mo, Suifen
Zhan, Ruoting
Yan, Ping
author_facet Xiao, Luhua
Lu, Xiaoying
Yang, Huilin
Lin, Cuiqing
Li, Le
Ni, Chen
Fang, Yuan
Mo, Suifen
Zhan, Ruoting
Yan, Ping
author_sort Xiao, Luhua
collection PubMed
description In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antioxidant activities in the antiradical activity test and the FRAP assay. The half-inhibition concentration (IC50) for MTF and F30 were 5.323 µg/mL and 5.278 µg/mL, respectively. MTF at 200 µg/mL significantly decreased the accumulation of TG in oleic acid (OA)-induced HepG2 cells and reversed the inhibitory effect of Compound C on AMPK (MTF and F30 significantly increased the glucose utilization of insulin-induced HepG2 cells). In addition, the components of MTF were identified by HPLC-MS, which were caffeic acid, quercetin 3-O-galactoside, isoquercetin, astragalin, rosmarinic acid, aromadendrin-3-O-rutinoside, rosmarinic acid-3-O-glucoside and kaempferol-7-O-glucoside. Through statistical correlations by Simca P software, it was found that the main antioxidant and hypolipidemic components of MCB might be caffeic acid, kaempferol-7-O-glucoside, rosmarinic acid-3-O-glucoside and aromadendrin-3-O-rutinoside, which may play important roles in the AMPK pathway. MTF and F30 in MCB could be potential health products for the treatment of hyperlipidemia.
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spelling pubmed-91823262022-06-10 The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts Xiao, Luhua Lu, Xiaoying Yang, Huilin Lin, Cuiqing Li, Le Ni, Chen Fang, Yuan Mo, Suifen Zhan, Ruoting Yan, Ping Molecules Article In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antioxidant activities in the antiradical activity test and the FRAP assay. The half-inhibition concentration (IC50) for MTF and F30 were 5.323 µg/mL and 5.278 µg/mL, respectively. MTF at 200 µg/mL significantly decreased the accumulation of TG in oleic acid (OA)-induced HepG2 cells and reversed the inhibitory effect of Compound C on AMPK (MTF and F30 significantly increased the glucose utilization of insulin-induced HepG2 cells). In addition, the components of MTF were identified by HPLC-MS, which were caffeic acid, quercetin 3-O-galactoside, isoquercetin, astragalin, rosmarinic acid, aromadendrin-3-O-rutinoside, rosmarinic acid-3-O-glucoside and kaempferol-7-O-glucoside. Through statistical correlations by Simca P software, it was found that the main antioxidant and hypolipidemic components of MCB might be caffeic acid, kaempferol-7-O-glucoside, rosmarinic acid-3-O-glucoside and aromadendrin-3-O-rutinoside, which may play important roles in the AMPK pathway. MTF and F30 in MCB could be potential health products for the treatment of hyperlipidemia. MDPI 2022-05-26 /pmc/articles/PMC9182326/ /pubmed/35684361 http://dx.doi.org/10.3390/molecules27113423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xiao, Luhua
Lu, Xiaoying
Yang, Huilin
Lin, Cuiqing
Li, Le
Ni, Chen
Fang, Yuan
Mo, Suifen
Zhan, Ruoting
Yan, Ping
The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title_full The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title_fullStr The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title_full_unstemmed The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title_short The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
title_sort antioxidant and hypolipidemic effects of mesona chinensis benth extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182326/
https://www.ncbi.nlm.nih.gov/pubmed/35684361
http://dx.doi.org/10.3390/molecules27113423
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