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The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts
In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antio...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182326/ https://www.ncbi.nlm.nih.gov/pubmed/35684361 http://dx.doi.org/10.3390/molecules27113423 |
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author | Xiao, Luhua Lu, Xiaoying Yang, Huilin Lin, Cuiqing Li, Le Ni, Chen Fang, Yuan Mo, Suifen Zhan, Ruoting Yan, Ping |
author_facet | Xiao, Luhua Lu, Xiaoying Yang, Huilin Lin, Cuiqing Li, Le Ni, Chen Fang, Yuan Mo, Suifen Zhan, Ruoting Yan, Ping |
author_sort | Xiao, Luhua |
collection | PubMed |
description | In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antioxidant activities in the antiradical activity test and the FRAP assay. The half-inhibition concentration (IC50) for MTF and F30 were 5.323 µg/mL and 5.278 µg/mL, respectively. MTF at 200 µg/mL significantly decreased the accumulation of TG in oleic acid (OA)-induced HepG2 cells and reversed the inhibitory effect of Compound C on AMPK (MTF and F30 significantly increased the glucose utilization of insulin-induced HepG2 cells). In addition, the components of MTF were identified by HPLC-MS, which were caffeic acid, quercetin 3-O-galactoside, isoquercetin, astragalin, rosmarinic acid, aromadendrin-3-O-rutinoside, rosmarinic acid-3-O-glucoside and kaempferol-7-O-glucoside. Through statistical correlations by Simca P software, it was found that the main antioxidant and hypolipidemic components of MCB might be caffeic acid, kaempferol-7-O-glucoside, rosmarinic acid-3-O-glucoside and aromadendrin-3-O-rutinoside, which may play important roles in the AMPK pathway. MTF and F30 in MCB could be potential health products for the treatment of hyperlipidemia. |
format | Online Article Text |
id | pubmed-9182326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91823262022-06-10 The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts Xiao, Luhua Lu, Xiaoying Yang, Huilin Lin, Cuiqing Li, Le Ni, Chen Fang, Yuan Mo, Suifen Zhan, Ruoting Yan, Ping Molecules Article In this study, the antioxidant and hypolipidemic effects of Mesona Chinensis Benth (MCB) extracts were evaluated. Seven fractions (F0, F10, F20, F30, F40, F50 and MTF) were obtained from the MCB ethanol extracts. Compared to the commercial antioxidants (vitamin C), MTF and F30 exhibited higher antioxidant activities in the antiradical activity test and the FRAP assay. The half-inhibition concentration (IC50) for MTF and F30 were 5.323 µg/mL and 5.278 µg/mL, respectively. MTF at 200 µg/mL significantly decreased the accumulation of TG in oleic acid (OA)-induced HepG2 cells and reversed the inhibitory effect of Compound C on AMPK (MTF and F30 significantly increased the glucose utilization of insulin-induced HepG2 cells). In addition, the components of MTF were identified by HPLC-MS, which were caffeic acid, quercetin 3-O-galactoside, isoquercetin, astragalin, rosmarinic acid, aromadendrin-3-O-rutinoside, rosmarinic acid-3-O-glucoside and kaempferol-7-O-glucoside. Through statistical correlations by Simca P software, it was found that the main antioxidant and hypolipidemic components of MCB might be caffeic acid, kaempferol-7-O-glucoside, rosmarinic acid-3-O-glucoside and aromadendrin-3-O-rutinoside, which may play important roles in the AMPK pathway. MTF and F30 in MCB could be potential health products for the treatment of hyperlipidemia. MDPI 2022-05-26 /pmc/articles/PMC9182326/ /pubmed/35684361 http://dx.doi.org/10.3390/molecules27113423 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xiao, Luhua Lu, Xiaoying Yang, Huilin Lin, Cuiqing Li, Le Ni, Chen Fang, Yuan Mo, Suifen Zhan, Ruoting Yan, Ping The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title | The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title_full | The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title_fullStr | The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title_full_unstemmed | The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title_short | The Antioxidant and Hypolipidemic Effects of Mesona Chinensis Benth Extracts |
title_sort | antioxidant and hypolipidemic effects of mesona chinensis benth extracts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182326/ https://www.ncbi.nlm.nih.gov/pubmed/35684361 http://dx.doi.org/10.3390/molecules27113423 |
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