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Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors

We examined whether the often-reported protective association of alcohol with cardiovascular disease (CVD) risk could arise from confounding. Our sample comprised 908 men (56–67 years), free of prevalent CVD. Participants were categorized into 6 groups: never drinkers, former drinkers, and very ligh...

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Autores principales: McEvoy, Linda K., Bergstrom, Jaclyn, Tu, Xinming, Garduno, Alexis C., Cummins, Kevin M., Franz, Carol E., Lyons, Michael J., Reynolds, Chandra A., Kremen, William S., Panizzon, Matthew S., Laughlin, Gail A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182350/
https://www.ncbi.nlm.nih.gov/pubmed/35683983
http://dx.doi.org/10.3390/nu14112183
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author McEvoy, Linda K.
Bergstrom, Jaclyn
Tu, Xinming
Garduno, Alexis C.
Cummins, Kevin M.
Franz, Carol E.
Lyons, Michael J.
Reynolds, Chandra A.
Kremen, William S.
Panizzon, Matthew S.
Laughlin, Gail A.
author_facet McEvoy, Linda K.
Bergstrom, Jaclyn
Tu, Xinming
Garduno, Alexis C.
Cummins, Kevin M.
Franz, Carol E.
Lyons, Michael J.
Reynolds, Chandra A.
Kremen, William S.
Panizzon, Matthew S.
Laughlin, Gail A.
author_sort McEvoy, Linda K.
collection PubMed
description We examined whether the often-reported protective association of alcohol with cardiovascular disease (CVD) risk could arise from confounding. Our sample comprised 908 men (56–67 years), free of prevalent CVD. Participants were categorized into 6 groups: never drinkers, former drinkers, and very light (1–4 drinks in past 14 days), light (5–14 drinks), moderate (15–28 drinks), and at-risk (>28 drinks) drinkers. Generalized linear mixed effect models examined the associations of alcohol use with three established CVD risk scores: The Framingham Risk Score (FRS); the atherosclerotic CVD (ASCVD) risk score; and the Metabolic Syndrome (MetS) Severity score, adjusting for group differences in demographics, body size, and health-related behaviors. In separate models we additionally adjusted for several groups of potentially explanatory factors including socioeconomic status, social support, physical and mental health status, childhood factors, and prior history of alcohol misuse. Results showed lower CVD risk among light and moderate alcohol drinkers, relative to very light drinkers, for all CVD risk scores, independent of demographics, body size, and health-related behaviors. Alcohol-CVD risk associations were robust to further adjustment for several groups of potential explanatory factors. Study limitations include the all-male sample with limited racial and ethnic diversity, and the inability to adjust for sugar consumption and for patterns of alcohol consumption. Although this observational study does not address causation, results show that middle-aged men who consume alcohol in moderation have lower CVD risk and better cardiometabolic health than men who consume little or no alcohol, independent of a variety of health, behavioral, psychosocial, and earlier life factors.
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spelling pubmed-91823502022-06-10 Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors McEvoy, Linda K. Bergstrom, Jaclyn Tu, Xinming Garduno, Alexis C. Cummins, Kevin M. Franz, Carol E. Lyons, Michael J. Reynolds, Chandra A. Kremen, William S. Panizzon, Matthew S. Laughlin, Gail A. Nutrients Article We examined whether the often-reported protective association of alcohol with cardiovascular disease (CVD) risk could arise from confounding. Our sample comprised 908 men (56–67 years), free of prevalent CVD. Participants were categorized into 6 groups: never drinkers, former drinkers, and very light (1–4 drinks in past 14 days), light (5–14 drinks), moderate (15–28 drinks), and at-risk (>28 drinks) drinkers. Generalized linear mixed effect models examined the associations of alcohol use with three established CVD risk scores: The Framingham Risk Score (FRS); the atherosclerotic CVD (ASCVD) risk score; and the Metabolic Syndrome (MetS) Severity score, adjusting for group differences in demographics, body size, and health-related behaviors. In separate models we additionally adjusted for several groups of potentially explanatory factors including socioeconomic status, social support, physical and mental health status, childhood factors, and prior history of alcohol misuse. Results showed lower CVD risk among light and moderate alcohol drinkers, relative to very light drinkers, for all CVD risk scores, independent of demographics, body size, and health-related behaviors. Alcohol-CVD risk associations were robust to further adjustment for several groups of potential explanatory factors. Study limitations include the all-male sample with limited racial and ethnic diversity, and the inability to adjust for sugar consumption and for patterns of alcohol consumption. Although this observational study does not address causation, results show that middle-aged men who consume alcohol in moderation have lower CVD risk and better cardiometabolic health than men who consume little or no alcohol, independent of a variety of health, behavioral, psychosocial, and earlier life factors. MDPI 2022-05-24 /pmc/articles/PMC9182350/ /pubmed/35683983 http://dx.doi.org/10.3390/nu14112183 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
McEvoy, Linda K.
Bergstrom, Jaclyn
Tu, Xinming
Garduno, Alexis C.
Cummins, Kevin M.
Franz, Carol E.
Lyons, Michael J.
Reynolds, Chandra A.
Kremen, William S.
Panizzon, Matthew S.
Laughlin, Gail A.
Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title_full Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title_fullStr Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title_full_unstemmed Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title_short Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in Middle-Aged Men Independent of Health, Behavior, Psychosocial, and Earlier Life Factors
title_sort moderate alcohol use is associated with reduced cardiovascular risk in middle-aged men independent of health, behavior, psychosocial, and earlier life factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182350/
https://www.ncbi.nlm.nih.gov/pubmed/35683983
http://dx.doi.org/10.3390/nu14112183
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