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A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines

We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel r...

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Detalles Bibliográficos
Autores principales:	Chamakuri, Srinivas, Tang, Sunny Ann, Tran, Kevin A., Guduru, Shiva Krishna Reddy, Bolin, Peter K., MacKenzie, Kevin R., Young, Damian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182393/ https://www.ncbi.nlm.nih.gov/pubmed/35684357 http://dx.doi.org/10.3390/molecules27113419

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