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Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies

Hypertension is a major cardiovascular risk factor that is responsible for a heavy burden of morbidity and mortality worldwide. A critical aspect of cardiovascular risk estimation in hypertensive patients depends on the assessment of hypertension-mediated organ damage (HMOD), namely the generalized...

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Autores principales: Del Pinto, Rita, Mulè, Giuseppe, Vadalà, Maria, Carollo, Caterina, Cottone, Santina, Agabiti Rosei, Claudia, De Ciuceis, Carolina, Rizzoni, Damiano, Ferri, Claudio, Muiesan, Maria Lorenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182467/
https://www.ncbi.nlm.nih.gov/pubmed/35683999
http://dx.doi.org/10.3390/nu14112200
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author Del Pinto, Rita
Mulè, Giuseppe
Vadalà, Maria
Carollo, Caterina
Cottone, Santina
Agabiti Rosei, Claudia
De Ciuceis, Carolina
Rizzoni, Damiano
Ferri, Claudio
Muiesan, Maria Lorenza
author_facet Del Pinto, Rita
Mulè, Giuseppe
Vadalà, Maria
Carollo, Caterina
Cottone, Santina
Agabiti Rosei, Claudia
De Ciuceis, Carolina
Rizzoni, Damiano
Ferri, Claudio
Muiesan, Maria Lorenza
author_sort Del Pinto, Rita
collection PubMed
description Hypertension is a major cardiovascular risk factor that is responsible for a heavy burden of morbidity and mortality worldwide. A critical aspect of cardiovascular risk estimation in hypertensive patients depends on the assessment of hypertension-mediated organ damage (HMOD), namely the generalized structural and functional changes in major organs induced by persistently elevated blood pressure values. The vasculature of the eye shares several common structural, functional, and embryological features with that of the heart, brain, and kidney. Since retinal microcirculation offers the unique advantage of being directly accessible to non-invasive and relatively simple investigation tools, there has been considerable interest in the development and modernization of techniques that allow the assessment of the retinal vessels’ structural and functional features in health and disease. With the advent of artificial intelligence and the application of sophisticated physics technologies to human sciences, consistent steps forward have been made in the study of the ocular fundus as a privileged site for diagnostic and prognostic assessment of diverse disease conditions. In this narrative review, we will recapitulate the main ocular imaging techniques that are currently relevant from a clinical and/or research standpoint, with reference to their pathophysiological basis and their possible diagnostic and prognostic relevance. A possible non pharmacological approach to prevent the onset and progression of retinopathy in the presence of hypertension and related cardiovascular risk factors and diseases will also be discussed.
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spelling pubmed-91824672022-06-10 Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies Del Pinto, Rita Mulè, Giuseppe Vadalà, Maria Carollo, Caterina Cottone, Santina Agabiti Rosei, Claudia De Ciuceis, Carolina Rizzoni, Damiano Ferri, Claudio Muiesan, Maria Lorenza Nutrients Review Hypertension is a major cardiovascular risk factor that is responsible for a heavy burden of morbidity and mortality worldwide. A critical aspect of cardiovascular risk estimation in hypertensive patients depends on the assessment of hypertension-mediated organ damage (HMOD), namely the generalized structural and functional changes in major organs induced by persistently elevated blood pressure values. The vasculature of the eye shares several common structural, functional, and embryological features with that of the heart, brain, and kidney. Since retinal microcirculation offers the unique advantage of being directly accessible to non-invasive and relatively simple investigation tools, there has been considerable interest in the development and modernization of techniques that allow the assessment of the retinal vessels’ structural and functional features in health and disease. With the advent of artificial intelligence and the application of sophisticated physics technologies to human sciences, consistent steps forward have been made in the study of the ocular fundus as a privileged site for diagnostic and prognostic assessment of diverse disease conditions. In this narrative review, we will recapitulate the main ocular imaging techniques that are currently relevant from a clinical and/or research standpoint, with reference to their pathophysiological basis and their possible diagnostic and prognostic relevance. A possible non pharmacological approach to prevent the onset and progression of retinopathy in the presence of hypertension and related cardiovascular risk factors and diseases will also be discussed. MDPI 2022-05-25 /pmc/articles/PMC9182467/ /pubmed/35683999 http://dx.doi.org/10.3390/nu14112200 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Del Pinto, Rita
Mulè, Giuseppe
Vadalà, Maria
Carollo, Caterina
Cottone, Santina
Agabiti Rosei, Claudia
De Ciuceis, Carolina
Rizzoni, Damiano
Ferri, Claudio
Muiesan, Maria Lorenza
Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title_full Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title_fullStr Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title_full_unstemmed Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title_short Arterial Hypertension and the Hidden Disease of the Eye: Diagnostic Tools and Therapeutic Strategies
title_sort arterial hypertension and the hidden disease of the eye: diagnostic tools and therapeutic strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182467/
https://www.ncbi.nlm.nih.gov/pubmed/35683999
http://dx.doi.org/10.3390/nu14112200
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