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Synthetic Access to Aromatic α-Haloketones

α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty...

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Autores principales: Porré, Marre, Pisanò, Gianmarco, Nahra, Fady, Cazin, Catherine S. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182500/
https://www.ncbi.nlm.nih.gov/pubmed/35684526
http://dx.doi.org/10.3390/molecules27113583
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author Porré, Marre
Pisanò, Gianmarco
Nahra, Fady
Cazin, Catherine S. J.
author_facet Porré, Marre
Pisanò, Gianmarco
Nahra, Fady
Cazin, Catherine S. J.
author_sort Porré, Marre
collection PubMed
description α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability.
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spelling pubmed-91825002022-06-10 Synthetic Access to Aromatic α-Haloketones Porré, Marre Pisanò, Gianmarco Nahra, Fady Cazin, Catherine S. J. Molecules Review α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability. MDPI 2022-06-02 /pmc/articles/PMC9182500/ /pubmed/35684526 http://dx.doi.org/10.3390/molecules27113583 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Porré, Marre
Pisanò, Gianmarco
Nahra, Fady
Cazin, Catherine S. J.
Synthetic Access to Aromatic α-Haloketones
title Synthetic Access to Aromatic α-Haloketones
title_full Synthetic Access to Aromatic α-Haloketones
title_fullStr Synthetic Access to Aromatic α-Haloketones
title_full_unstemmed Synthetic Access to Aromatic α-Haloketones
title_short Synthetic Access to Aromatic α-Haloketones
title_sort synthetic access to aromatic α-haloketones
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182500/
https://www.ncbi.nlm.nih.gov/pubmed/35684526
http://dx.doi.org/10.3390/molecules27113583
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