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Synthetic Access to Aromatic α-Haloketones
α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182500/ https://www.ncbi.nlm.nih.gov/pubmed/35684526 http://dx.doi.org/10.3390/molecules27113583 |
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author | Porré, Marre Pisanò, Gianmarco Nahra, Fady Cazin, Catherine S. J. |
author_facet | Porré, Marre Pisanò, Gianmarco Nahra, Fady Cazin, Catherine S. J. |
author_sort | Porré, Marre |
collection | PubMed |
description | α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability. |
format | Online Article Text |
id | pubmed-9182500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91825002022-06-10 Synthetic Access to Aromatic α-Haloketones Porré, Marre Pisanò, Gianmarco Nahra, Fady Cazin, Catherine S. J. Molecules Review α-Haloketones play an essential role in the synthesis of complex N-, S-, O-heterocycles; of which some exhibit a remarkable biological activity. Research further illustrated that α-bromo-, α-chloro-, and α-iodoketones are key precursors for blockbuster pharmacological compounds. Over the past twenty years, substantial advances have been made in the synthesis of these industrially relevant building blocks. Efforts have focused on rendering the synthetic protocols greener, more effective and versatile. In this survey, we summarised and thoroughly evaluated the progress of the field, established in the past two decades, in terms of generality, efficacy and sustainability. MDPI 2022-06-02 /pmc/articles/PMC9182500/ /pubmed/35684526 http://dx.doi.org/10.3390/molecules27113583 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Porré, Marre Pisanò, Gianmarco Nahra, Fady Cazin, Catherine S. J. Synthetic Access to Aromatic α-Haloketones |
title | Synthetic Access to Aromatic α-Haloketones |
title_full | Synthetic Access to Aromatic α-Haloketones |
title_fullStr | Synthetic Access to Aromatic α-Haloketones |
title_full_unstemmed | Synthetic Access to Aromatic α-Haloketones |
title_short | Synthetic Access to Aromatic α-Haloketones |
title_sort | synthetic access to aromatic α-haloketones |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182500/ https://www.ncbi.nlm.nih.gov/pubmed/35684526 http://dx.doi.org/10.3390/molecules27113583 |
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