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Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies

Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of...

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Autores principales: Rohmann, Nathalie, Munthe, Liasita, Schlicht, Kristina, Geisler, Corinna, Demetrowitsch, Tobias J., Bang, Corinna, Jensen-Kroll, Julia, Türk, Kathrin, Bacher, Petra, Franke, Andre, Schwarz, Karin, Schulte, Dominik M., Laudes, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182605/
https://www.ncbi.nlm.nih.gov/pubmed/35684151
http://dx.doi.org/10.3390/nu14112351
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author Rohmann, Nathalie
Munthe, Liasita
Schlicht, Kristina
Geisler, Corinna
Demetrowitsch, Tobias J.
Bang, Corinna
Jensen-Kroll, Julia
Türk, Kathrin
Bacher, Petra
Franke, Andre
Schwarz, Karin
Schulte, Dominik M.
Laudes, Matthias
author_facet Rohmann, Nathalie
Munthe, Liasita
Schlicht, Kristina
Geisler, Corinna
Demetrowitsch, Tobias J.
Bang, Corinna
Jensen-Kroll, Julia
Türk, Kathrin
Bacher, Petra
Franke, Andre
Schwarz, Karin
Schulte, Dominik M.
Laudes, Matthias
author_sort Rohmann, Nathalie
collection PubMed
description Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, n = 385 allergy cases, either hay fever (=type I allergy, n = 183) or contact allergy (=type IV allergy, n = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total n = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions.
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spelling pubmed-91826052022-06-10 Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies Rohmann, Nathalie Munthe, Liasita Schlicht, Kristina Geisler, Corinna Demetrowitsch, Tobias J. Bang, Corinna Jensen-Kroll, Julia Türk, Kathrin Bacher, Petra Franke, Andre Schwarz, Karin Schulte, Dominik M. Laudes, Matthias Nutrients Article Background: Alongside metabolic diseases (esp. obesity), allergic disorders are becoming increasingly prevalent. Since both obesity and allergies are highly impacted by environmental determinants, with this study we assessed the potential link between metabolic implications and two distinct types of allergies. Methods: Using cross-sectional data from the German FoCus cohort, n = 385 allergy cases, either hay fever (=type I allergy, n = 183) or contact allergy (=type IV allergy, n = 202) were compared to age- and sex-matched healthy control subjects (1:1 ratio, in total n = 770) regarding their metabolic phenotype, diet, physical activity, sleep, gut microbial composition, and serum metabolite profile using suitable BMI-adjusted models. Results: Obesity and metabolic alterations were found significantly more prevalent in subjects with allergies. In fact, this relation was more pronounced in contact allergy than hay fever. Subsequent BMI-adjusted analysis reveals particular importance of co-occurring hyperlipidaemia for both allergy types. For contact allergy, we revealed a strong association to the dietary intake of poly-unsaturated fatty acids, particularly α-linolenic acid, as well as the enrichment of the corresponding metabolic pathway. For hay fever, there were no major associations to the diet but to a lower physical activity level, shorter duration of sleep, and an altered gut microbial composition. Finally, genetic predisposition for hyperlipidaemia was associated to both contact allergy and hay fever. Conclusions: Reflected by higher allergy prevalence, our findings indicate an impaired immune response in obesity and hyperlipidaemia, which is differentially regulated in type I and type IV allergies by an unfavourable lifestyle constellation and subsequent microbial and metabolic dysfunctions. MDPI 2022-06-05 /pmc/articles/PMC9182605/ /pubmed/35684151 http://dx.doi.org/10.3390/nu14112351 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rohmann, Nathalie
Munthe, Liasita
Schlicht, Kristina
Geisler, Corinna
Demetrowitsch, Tobias J.
Bang, Corinna
Jensen-Kroll, Julia
Türk, Kathrin
Bacher, Petra
Franke, Andre
Schwarz, Karin
Schulte, Dominik M.
Laudes, Matthias
Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title_full Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title_fullStr Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title_full_unstemmed Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title_short Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies
title_sort differential effects of obesity, hyperlipidaemia, dietary intake and physical inactivity on type i versus type iv allergies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182605/
https://www.ncbi.nlm.nih.gov/pubmed/35684151
http://dx.doi.org/10.3390/nu14112351
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