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Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents

Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned...

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Autores principales: Morrissey, Christopher, Amiot, Marie-Josèphe, Goncalves, Aurelie, Raverdy, Cecile, Masson, Delphine, Tardivel, Catherine, Gayrard, Sandrine, Carrère, Myriam, Landrier, Jean-Francois, Vinet, Agnes, Perez-Martin, Antonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182680/
https://www.ncbi.nlm.nih.gov/pubmed/35684098
http://dx.doi.org/10.3390/nu14112296
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author Morrissey, Christopher
Amiot, Marie-Josèphe
Goncalves, Aurelie
Raverdy, Cecile
Masson, Delphine
Tardivel, Catherine
Gayrard, Sandrine
Carrère, Myriam
Landrier, Jean-Francois
Vinet, Agnes
Perez-Martin, Antonia
author_facet Morrissey, Christopher
Amiot, Marie-Josèphe
Goncalves, Aurelie
Raverdy, Cecile
Masson, Delphine
Tardivel, Catherine
Gayrard, Sandrine
Carrère, Myriam
Landrier, Jean-Francois
Vinet, Agnes
Perez-Martin, Antonia
author_sort Morrissey, Christopher
collection PubMed
description Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (n = 13), a lifestyle program without VD supplementation (n = 13) or a control group composed of normal-weight adolescents (n = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (r = −0.59, p = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents.
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spelling pubmed-91826802022-06-10 Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents Morrissey, Christopher Amiot, Marie-Josèphe Goncalves, Aurelie Raverdy, Cecile Masson, Delphine Tardivel, Catherine Gayrard, Sandrine Carrère, Myriam Landrier, Jean-Francois Vinet, Agnes Perez-Martin, Antonia Nutrients Article Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (n = 13), a lifestyle program without VD supplementation (n = 13) or a control group composed of normal-weight adolescents (n = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (r = −0.59, p = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents. MDPI 2022-05-30 /pmc/articles/PMC9182680/ /pubmed/35684098 http://dx.doi.org/10.3390/nu14112296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morrissey, Christopher
Amiot, Marie-Josèphe
Goncalves, Aurelie
Raverdy, Cecile
Masson, Delphine
Tardivel, Catherine
Gayrard, Sandrine
Carrère, Myriam
Landrier, Jean-Francois
Vinet, Agnes
Perez-Martin, Antonia
Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title_full Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title_fullStr Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title_full_unstemmed Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title_short Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
title_sort vitamin d supplementation on carotid remodeling and stiffness in obese adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182680/
https://www.ncbi.nlm.nih.gov/pubmed/35684098
http://dx.doi.org/10.3390/nu14112296
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