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Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents
Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182680/ https://www.ncbi.nlm.nih.gov/pubmed/35684098 http://dx.doi.org/10.3390/nu14112296 |
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author | Morrissey, Christopher Amiot, Marie-Josèphe Goncalves, Aurelie Raverdy, Cecile Masson, Delphine Tardivel, Catherine Gayrard, Sandrine Carrère, Myriam Landrier, Jean-Francois Vinet, Agnes Perez-Martin, Antonia |
author_facet | Morrissey, Christopher Amiot, Marie-Josèphe Goncalves, Aurelie Raverdy, Cecile Masson, Delphine Tardivel, Catherine Gayrard, Sandrine Carrère, Myriam Landrier, Jean-Francois Vinet, Agnes Perez-Martin, Antonia |
author_sort | Morrissey, Christopher |
collection | PubMed |
description | Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (n = 13), a lifestyle program without VD supplementation (n = 13) or a control group composed of normal-weight adolescents (n = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (r = −0.59, p = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents. |
format | Online Article Text |
id | pubmed-9182680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91826802022-06-10 Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents Morrissey, Christopher Amiot, Marie-Josèphe Goncalves, Aurelie Raverdy, Cecile Masson, Delphine Tardivel, Catherine Gayrard, Sandrine Carrère, Myriam Landrier, Jean-Francois Vinet, Agnes Perez-Martin, Antonia Nutrients Article Obesity is associated with vitamin D (VD) deficiency and arterial stiffness. This randomized control trial assessed the effects of VD supplementation during a weight-loss program on carotid intima-media thickness (IMT) and carotid compliance in obese adolescents. Participants were randomly assigned to receive either a 12-week lifestyle program with VD supplementation (n = 13), a lifestyle program without VD supplementation (n = 13) or a control group composed of normal-weight adolescents (n = 18). Serum total and free 25-hydroxyvitamin D (25(OH)D), IMT and carotid compliance were measured before and after the trial. Insufficiency in 25(OH)D concentration was found in 73% of obese participants compared to 22% among controls. Obese adolescents had lower free 25(OH)D and displayed higher IMT but lower carotid compliance than controls. Free 25(OH)D and IMT were negatively correlated in adolescents displaying VD insufficiency at baseline. After three months, total and free 25(OH)D increased in both groups. The changes of IMT and carotid compliance were similar between groups. The changes in IMT were correlated with the changes in total 25(OH)D in obese adolescents with VD insufficiency at baseline (r = −0.59, p = 0.03). While the lifestyle program with VD supplementation did not affect carotid compliance, IMT reduction was improved in obese adolescents. MDPI 2022-05-30 /pmc/articles/PMC9182680/ /pubmed/35684098 http://dx.doi.org/10.3390/nu14112296 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Morrissey, Christopher Amiot, Marie-Josèphe Goncalves, Aurelie Raverdy, Cecile Masson, Delphine Tardivel, Catherine Gayrard, Sandrine Carrère, Myriam Landrier, Jean-Francois Vinet, Agnes Perez-Martin, Antonia Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title_full | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title_fullStr | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title_full_unstemmed | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title_short | Vitamin D Supplementation on Carotid Remodeling and Stiffness in Obese Adolescents |
title_sort | vitamin d supplementation on carotid remodeling and stiffness in obese adolescents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182680/ https://www.ncbi.nlm.nih.gov/pubmed/35684098 http://dx.doi.org/10.3390/nu14112296 |
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