Quantitative regulation of the thermal stability of enveloped virus vaccines by surface charge engineering to prevent the self-aggregation of attachment glycoproteins

The development of thermostable vaccines can relieve the bottleneck of existing vaccines caused by thermal instability and subsequent poor efficacy, which is one of the predominant reasons for the millions of deaths caused by vaccine-preventable diseases. Research into the mechanism of viral thermos...

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Detalles Bibliográficos
Autores principales: Shang, Yu, Li, Li, Zhang, Tengfei, Luo, Qingping, Yu, Qingzhong, Zeng, Zhe, Li, Lintao, Jia, Miaomiao, Tang, Guoyi, Fan, Sanlin, Lu, Qin, Zhang, Wenting, Xue, Yuhan, Wang, Hongling, Liu, Wei, Wang, Hongcai, Zhang, Rongrong, Ding, Chan, Shao, Huabin, Wen, Guoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182686/
https://www.ncbi.nlm.nih.gov/pubmed/35679257
http://dx.doi.org/10.1371/journal.ppat.1010564

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