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The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence

Chronic diseases develop via complex pathways, depending on the degree of exposure to risk factors from early in life and childhood onward. Metabolic syndrome has multiple risk factors, including genetic factors, inappropriate diet, and insufficient physical activity. This study classified health-re...

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Autores principales: Kim, Ui-Jeong, Choi, Eun-Jeong, Park, Hyunjin, Lee, Hye-Ah, Park, Bomi, Kim, Haesoon, Hong, Youngsun, Jung, Seungyoun, Park, Hyesook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182841/
https://www.ncbi.nlm.nih.gov/pubmed/35684139
http://dx.doi.org/10.3390/nu14112339
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author Kim, Ui-Jeong
Choi, Eun-Jeong
Park, Hyunjin
Lee, Hye-Ah
Park, Bomi
Kim, Haesoon
Hong, Youngsun
Jung, Seungyoun
Park, Hyesook
author_facet Kim, Ui-Jeong
Choi, Eun-Jeong
Park, Hyunjin
Lee, Hye-Ah
Park, Bomi
Kim, Haesoon
Hong, Youngsun
Jung, Seungyoun
Park, Hyesook
author_sort Kim, Ui-Jeong
collection PubMed
description Chronic diseases develop via complex pathways, depending on the degree of exposure to risk factors from early in life and childhood onward. Metabolic syndrome has multiple risk factors, including genetic factors, inappropriate diet, and insufficient physical activity. This study classified health-related behavior classes in childhood and adolescents and analyzed the direct and indirect effects of each class on the metabolic risk in inflammation-mediated pathways. We identified the health-related lifestyle classes based on health-related behavior indicators in subjects aged 3–15 years who participated in the Ewha Birth and Growth Cohort Study by using a latent class analysis. A mediation analysis was performed to access the direct and indirect effects of each class on the continuous metabolic syndrome score (cMetS), with the inflammatory index used as a mediating factor. Subjects were classified into inactive and positive lifestyle classes according to their characteristics. In the inactive lifestyle class, interleukin (IL)-6 and cMetS had a significant association. The study confirmed that IL-6 exerts a significant indirect effect between inactive lifestyle and cMetS. This result supports previous studies. Since the health behaviors of children and adolescents can affect the likelihood of subsequent metabolic syndrome, appropriate health behavior interventions for this period are needed.
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spelling pubmed-91828412022-06-10 The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence Kim, Ui-Jeong Choi, Eun-Jeong Park, Hyunjin Lee, Hye-Ah Park, Bomi Kim, Haesoon Hong, Youngsun Jung, Seungyoun Park, Hyesook Nutrients Article Chronic diseases develop via complex pathways, depending on the degree of exposure to risk factors from early in life and childhood onward. Metabolic syndrome has multiple risk factors, including genetic factors, inappropriate diet, and insufficient physical activity. This study classified health-related behavior classes in childhood and adolescents and analyzed the direct and indirect effects of each class on the metabolic risk in inflammation-mediated pathways. We identified the health-related lifestyle classes based on health-related behavior indicators in subjects aged 3–15 years who participated in the Ewha Birth and Growth Cohort Study by using a latent class analysis. A mediation analysis was performed to access the direct and indirect effects of each class on the continuous metabolic syndrome score (cMetS), with the inflammatory index used as a mediating factor. Subjects were classified into inactive and positive lifestyle classes according to their characteristics. In the inactive lifestyle class, interleukin (IL)-6 and cMetS had a significant association. The study confirmed that IL-6 exerts a significant indirect effect between inactive lifestyle and cMetS. This result supports previous studies. Since the health behaviors of children and adolescents can affect the likelihood of subsequent metabolic syndrome, appropriate health behavior interventions for this period are needed. MDPI 2022-06-02 /pmc/articles/PMC9182841/ /pubmed/35684139 http://dx.doi.org/10.3390/nu14112339 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Ui-Jeong
Choi, Eun-Jeong
Park, Hyunjin
Lee, Hye-Ah
Park, Bomi
Kim, Haesoon
Hong, Youngsun
Jung, Seungyoun
Park, Hyesook
The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title_full The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title_fullStr The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title_full_unstemmed The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title_short The Mediating Effect of Inflammation between the Dietary and Health-Related Behaviors and Metabolic Syndrome in Adolescence
title_sort mediating effect of inflammation between the dietary and health-related behaviors and metabolic syndrome in adolescence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182841/
https://www.ncbi.nlm.nih.gov/pubmed/35684139
http://dx.doi.org/10.3390/nu14112339
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