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Sarcopenia and Mortality in Older Hemodialysis Patients
(1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182960/ https://www.ncbi.nlm.nih.gov/pubmed/35684154 http://dx.doi.org/10.3390/nu14112354 |
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author | Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Gracia-Iguacel, Carolina González-Ibarguren, Isabel Ortíz-Arduan, Alberto Mas-Fontao, Sebastian González-Parra, Emilio |
author_facet | Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Gracia-Iguacel, Carolina González-Ibarguren, Isabel Ortíz-Arduan, Alberto Mas-Fontao, Sebastian González-Parra, Emilio |
author_sort | Sánchez-Tocino, M. Luz |
collection | PubMed |
description | (1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14–8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04–10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes. |
format | Online Article Text |
id | pubmed-9182960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91829602022-06-10 Sarcopenia and Mortality in Older Hemodialysis Patients Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Gracia-Iguacel, Carolina González-Ibarguren, Isabel Ortíz-Arduan, Alberto Mas-Fontao, Sebastian González-Parra, Emilio Nutrients Article (1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14–8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04–10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes. MDPI 2022-06-05 /pmc/articles/PMC9182960/ /pubmed/35684154 http://dx.doi.org/10.3390/nu14112354 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Gracia-Iguacel, Carolina González-Ibarguren, Isabel Ortíz-Arduan, Alberto Mas-Fontao, Sebastian González-Parra, Emilio Sarcopenia and Mortality in Older Hemodialysis Patients |
title | Sarcopenia and Mortality in Older Hemodialysis Patients |
title_full | Sarcopenia and Mortality in Older Hemodialysis Patients |
title_fullStr | Sarcopenia and Mortality in Older Hemodialysis Patients |
title_full_unstemmed | Sarcopenia and Mortality in Older Hemodialysis Patients |
title_short | Sarcopenia and Mortality in Older Hemodialysis Patients |
title_sort | sarcopenia and mortality in older hemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182960/ https://www.ncbi.nlm.nih.gov/pubmed/35684154 http://dx.doi.org/10.3390/nu14112354 |
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