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Sarcopenia and Mortality in Older Hemodialysis Patients

(1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysi...

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Autores principales: Sánchez-Tocino, M. Luz, Miranda-Serrano, Blanca, López-González, Antonio, Villoria-González, Silvia, Pereira-García, Mónica, Gracia-Iguacel, Carolina, González-Ibarguren, Isabel, Ortíz-Arduan, Alberto, Mas-Fontao, Sebastian, González-Parra, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182960/
https://www.ncbi.nlm.nih.gov/pubmed/35684154
http://dx.doi.org/10.3390/nu14112354
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author Sánchez-Tocino, M. Luz
Miranda-Serrano, Blanca
López-González, Antonio
Villoria-González, Silvia
Pereira-García, Mónica
Gracia-Iguacel, Carolina
González-Ibarguren, Isabel
Ortíz-Arduan, Alberto
Mas-Fontao, Sebastian
González-Parra, Emilio
author_facet Sánchez-Tocino, M. Luz
Miranda-Serrano, Blanca
López-González, Antonio
Villoria-González, Silvia
Pereira-García, Mónica
Gracia-Iguacel, Carolina
González-Ibarguren, Isabel
Ortíz-Arduan, Alberto
Mas-Fontao, Sebastian
González-Parra, Emilio
author_sort Sánchez-Tocino, M. Luz
collection PubMed
description (1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14–8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04–10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes.
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spelling pubmed-91829602022-06-10 Sarcopenia and Mortality in Older Hemodialysis Patients Sánchez-Tocino, M. Luz Miranda-Serrano, Blanca López-González, Antonio Villoria-González, Silvia Pereira-García, Mónica Gracia-Iguacel, Carolina González-Ibarguren, Isabel Ortíz-Arduan, Alberto Mas-Fontao, Sebastian González-Parra, Emilio Nutrients Article (1) Sarcopenia is a progressive loss of skeletal muscle mass and strength. The aim of this study was to determine the association of sarcopenia, defined according to the Working Group on Sarcopenia in Older People (EWGSOP2) diagnostic criteria, with mortality at 24 months in very elderly hemodialysis patients. (2) A prospective study was conducted in 60 patients on chronic hemodialysis who were older than 75 years. Sarcopenia was diagnosed according to EWGSOP2 criteria. Additionally, clinical, anthropometric and analytical variables and body composition by bioimpedance were assessed. The date and cause of death were recorded during 2 years of follow-up. (3) Among study participants, 41 (68%) were men, the mean age 81.85 ± 5.58 years and the dialysis vintage was 49.88 ± 40.29 months. The prevalence of probable sarcopenia was 75% to 97%, depending on the criteria employed: confirmed sarcopenia ranged from 37 to 40%, and severe sarcopenia ranged from 18 to 37%. A total of 30 (50%) patients died over 24 months. Sarcopenia probability variables were not related to mortality. In contrast, sarcopenia confirmation (appendicular skeletal muscle mass, ASM) and severity (gait speed, GS) variables were associated with mortality. In multivariate analysis, the hazard ratio (95% confidence interval) for all-cause death was 3.03 (1.14–8.08, p = 0.028) for patients fulfilling ASM sarcopenia criteria and 3.29 (1.04–10.39, p = 0.042) for patients fulfilling GS sarcopenia criteria. (4) The diagnosis of sarcopenia by EWGSOP2 criteria is associated with an increased risk of all-cause death in elderly dialysis patients. Specifically, ASM and GS criteria could be used as mortality risk markers in elderly hemodialysis patients. Future studies should address whether the early diagnosis and treatment of sarcopenia improve outcomes. MDPI 2022-06-05 /pmc/articles/PMC9182960/ /pubmed/35684154 http://dx.doi.org/10.3390/nu14112354 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Tocino, M. Luz
Miranda-Serrano, Blanca
López-González, Antonio
Villoria-González, Silvia
Pereira-García, Mónica
Gracia-Iguacel, Carolina
González-Ibarguren, Isabel
Ortíz-Arduan, Alberto
Mas-Fontao, Sebastian
González-Parra, Emilio
Sarcopenia and Mortality in Older Hemodialysis Patients
title Sarcopenia and Mortality in Older Hemodialysis Patients
title_full Sarcopenia and Mortality in Older Hemodialysis Patients
title_fullStr Sarcopenia and Mortality in Older Hemodialysis Patients
title_full_unstemmed Sarcopenia and Mortality in Older Hemodialysis Patients
title_short Sarcopenia and Mortality in Older Hemodialysis Patients
title_sort sarcopenia and mortality in older hemodialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182960/
https://www.ncbi.nlm.nih.gov/pubmed/35684154
http://dx.doi.org/10.3390/nu14112354
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