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Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation
Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD), and affects their prognosis. The Controlling Nutritional Status (CONUT) score is a nutritional screening tool calculated using only blood test data. This study aimed to investigate the prognostic value of CONUT sco...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182995/ https://www.ncbi.nlm.nih.gov/pubmed/35684116 http://dx.doi.org/10.3390/nu14112317 |
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author | Takagi, Kimiaki Takahashi, Hiroshi Miura, Tomomi Yamagiwa, Kasumi Kawase, Kota Muramatsu-Maekawa, Yuka Koie, Takuya Mizuno, Masashi |
author_facet | Takagi, Kimiaki Takahashi, Hiroshi Miura, Tomomi Yamagiwa, Kasumi Kawase, Kota Muramatsu-Maekawa, Yuka Koie, Takuya Mizuno, Masashi |
author_sort | Takagi, Kimiaki |
collection | PubMed |
description | Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD), and affects their prognosis. The Controlling Nutritional Status (CONUT) score is a nutritional screening tool calculated using only blood test data. This study aimed to investigate the prognostic value of CONUT score in patients just initiating dialysis. A total of 311 CKD patients who stably initiated dialysis were enrolled. Only 27 (8.7%) patients were classified as having normal nutritional status. The CONUT score was also independently correlated with elevated C-reactive protein levels (β = 0.485, p < 0.0001). During the median follow-up of 37 months, 100 patients (32.2%) died. The CONUT score was an independent predictor of all-cause mortality (adjusted hazard ratio 1.13, 95% confidence interval 1.04–1.22, p < 0.0024). As model discrimination, the addition of the CONUT score to a prediction model based on established risk factors significantly improved net reclassification improvement (0.285, p = 0.028) and integrated discrimination improvement (0.025, p = 0.023). The CONUT score might be a simplified surrogate marker of the PEW with clinical utility and could predict all-cause mortality, in addition to improving the predictability in CKD patients just initiating dialysis. The CONUT score also could predict infectious-disease mortality. |
format | Online Article Text |
id | pubmed-9182995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-91829952022-06-10 Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation Takagi, Kimiaki Takahashi, Hiroshi Miura, Tomomi Yamagiwa, Kasumi Kawase, Kota Muramatsu-Maekawa, Yuka Koie, Takuya Mizuno, Masashi Nutrients Article Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD), and affects their prognosis. The Controlling Nutritional Status (CONUT) score is a nutritional screening tool calculated using only blood test data. This study aimed to investigate the prognostic value of CONUT score in patients just initiating dialysis. A total of 311 CKD patients who stably initiated dialysis were enrolled. Only 27 (8.7%) patients were classified as having normal nutritional status. The CONUT score was also independently correlated with elevated C-reactive protein levels (β = 0.485, p < 0.0001). During the median follow-up of 37 months, 100 patients (32.2%) died. The CONUT score was an independent predictor of all-cause mortality (adjusted hazard ratio 1.13, 95% confidence interval 1.04–1.22, p < 0.0024). As model discrimination, the addition of the CONUT score to a prediction model based on established risk factors significantly improved net reclassification improvement (0.285, p = 0.028) and integrated discrimination improvement (0.025, p = 0.023). The CONUT score might be a simplified surrogate marker of the PEW with clinical utility and could predict all-cause mortality, in addition to improving the predictability in CKD patients just initiating dialysis. The CONUT score also could predict infectious-disease mortality. MDPI 2022-05-31 /pmc/articles/PMC9182995/ /pubmed/35684116 http://dx.doi.org/10.3390/nu14112317 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Takagi, Kimiaki Takahashi, Hiroshi Miura, Tomomi Yamagiwa, Kasumi Kawase, Kota Muramatsu-Maekawa, Yuka Koie, Takuya Mizuno, Masashi Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title | Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title_full | Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title_fullStr | Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title_full_unstemmed | Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title_short | Prognostic Value of the Controlling Nutritional Status (CONUT) Score in Patients at Dialysis Initiation |
title_sort | prognostic value of the controlling nutritional status (conut) score in patients at dialysis initiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182995/ https://www.ncbi.nlm.nih.gov/pubmed/35684116 http://dx.doi.org/10.3390/nu14112317 |
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