Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses

In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hongbo, Yao, Yanfeng, Li, Yan, Chen, Jianjun, Chen, Ze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183062/
https://www.ncbi.nlm.nih.gov/pubmed/35694294
http://dx.doi.org/10.3389/fmicb.2022.896469
_version_ 1784724196788535296
author Zhang, Hongbo
Yao, Yanfeng
Li, Yan
Chen, Jianjun
Chen, Ze
author_facet Zhang, Hongbo
Yao, Yanfeng
Li, Yan
Chen, Jianjun
Chen, Ze
author_sort Zhang, Hongbo
collection PubMed
description In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics of some viruses isolated from water samples were extremely similar to those from lakeside poultry. Pathogenic experiments showed that selected represented isolates in this study were highly pathogenic for SPF chickens but had a diversified virulence in mice. The results of our study suggested the potential transmission of avian influenza (H5N1) between the poultry and wild waterfowls and water body around the habitat may play an important role.
format Online
Article
Text
id pubmed-9183062
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-91830622022-06-10 Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses Zhang, Hongbo Yao, Yanfeng Li, Yan Chen, Jianjun Chen, Ze Front Microbiol Microbiology In this study, we isolated 10 H5N1 strains from water samples in Dongting Lake and 4 H5N1 strains from lakeside backyard poultry. These isolates belonged to three distinct clades (clade 2.3.2, 2.3.4, and 7). Phylogenetic analysis showed a diversified genome constellation. The genetic characteristics of some viruses isolated from water samples were extremely similar to those from lakeside poultry. Pathogenic experiments showed that selected represented isolates in this study were highly pathogenic for SPF chickens but had a diversified virulence in mice. The results of our study suggested the potential transmission of avian influenza (H5N1) between the poultry and wild waterfowls and water body around the habitat may play an important role. Frontiers Media S.A. 2022-05-26 /pmc/articles/PMC9183062/ /pubmed/35694294 http://dx.doi.org/10.3389/fmicb.2022.896469 Text en Copyright © 2022 Zhang, Yao, Li, Chen and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Zhang, Hongbo
Yao, Yanfeng
Li, Yan
Chen, Jianjun
Chen, Ze
Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title_full Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title_fullStr Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title_full_unstemmed Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title_short Evidence for Water-Borne Transmission of Highly Pathogenic Avian Influenza H5N1 Viruses
title_sort evidence for water-borne transmission of highly pathogenic avian influenza h5n1 viruses
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183062/
https://www.ncbi.nlm.nih.gov/pubmed/35694294
http://dx.doi.org/10.3389/fmicb.2022.896469
work_keys_str_mv AT zhanghongbo evidenceforwaterbornetransmissionofhighlypathogenicavianinfluenzah5n1viruses
AT yaoyanfeng evidenceforwaterbornetransmissionofhighlypathogenicavianinfluenzah5n1viruses
AT liyan evidenceforwaterbornetransmissionofhighlypathogenicavianinfluenzah5n1viruses
AT chenjianjun evidenceforwaterbornetransmissionofhighlypathogenicavianinfluenzah5n1viruses
AT chenze evidenceforwaterbornetransmissionofhighlypathogenicavianinfluenzah5n1viruses

Ejemplares similares