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Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice

Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-...

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Autores principales: Yoon, Minseok, Jung, Jonghoon, Kim, Minjung, Lee, Changho, Cho, Suengmok, Um, Minyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183155/
https://www.ncbi.nlm.nih.gov/pubmed/35684048
http://dx.doi.org/10.3390/nu14112249
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author Yoon, Minseok
Jung, Jonghoon
Kim, Minjung
Lee, Changho
Cho, Suengmok
Um, Minyoung
author_facet Yoon, Minseok
Jung, Jonghoon
Kim, Minjung
Lee, Changho
Cho, Suengmok
Um, Minyoung
author_sort Yoon, Minseok
collection PubMed
description Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-induced sleep disruption and excitation in mice. Caffeine significantly decreased sleep duration in the pentobarbital-induced sleep test. It also resulted in a significant increase in sleep onset and a decrease in non-rapid eye movement sleep. Moreover, in an open-field test, caffeine-treated mice exhibited a significantly increased time in the center zone and total distance traveled. However, the co-administration of caffeine and PE did not result in similar arousal activities. Thus, our results suggest that PE can be used as a potential therapeutic agent to treat sleep problems and excitatory status associated with caffeine intake.
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spelling pubmed-91831552022-06-10 Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice Yoon, Minseok Jung, Jonghoon Kim, Minjung Lee, Changho Cho, Suengmok Um, Minyoung Nutrients Article Sleep is one of the most essential factors required to maintain good health. However, the global prevalence of insomnia is increasing, and caffeine intake is a major trigger. The objective of this study was to investigate the inhibitory effect of black pepper, Piper nigrum extract (PE), on caffeine-induced sleep disruption and excitation in mice. Caffeine significantly decreased sleep duration in the pentobarbital-induced sleep test. It also resulted in a significant increase in sleep onset and a decrease in non-rapid eye movement sleep. Moreover, in an open-field test, caffeine-treated mice exhibited a significantly increased time in the center zone and total distance traveled. However, the co-administration of caffeine and PE did not result in similar arousal activities. Thus, our results suggest that PE can be used as a potential therapeutic agent to treat sleep problems and excitatory status associated with caffeine intake. MDPI 2022-05-27 /pmc/articles/PMC9183155/ /pubmed/35684048 http://dx.doi.org/10.3390/nu14112249 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Minseok
Jung, Jonghoon
Kim, Minjung
Lee, Changho
Cho, Suengmok
Um, Minyoung
Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title_full Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title_fullStr Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title_full_unstemmed Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title_short Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice
title_sort effect of black pepper (piper nigrum) extract on caffeine-induced sleep disruption and excitation in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183155/
https://www.ncbi.nlm.nih.gov/pubmed/35684048
http://dx.doi.org/10.3390/nu14112249
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