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Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study

(1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesth...

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Autores principales: Seydou, Alassane, Arnould, Louis, Gabrielle, Pierre-Henry, Baudin, Florian, Ghezala, Ines Ben, Bron, Alain M., Acar, Niyazi, Creuzot-Garcher, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183164/
https://www.ncbi.nlm.nih.gov/pubmed/35684090
http://dx.doi.org/10.3390/nu14112290
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author Seydou, Alassane
Arnould, Louis
Gabrielle, Pierre-Henry
Baudin, Florian
Ghezala, Ines Ben
Bron, Alain M.
Acar, Niyazi
Creuzot-Garcher, Catherine
author_facet Seydou, Alassane
Arnould, Louis
Gabrielle, Pierre-Henry
Baudin, Florian
Ghezala, Ines Ben
Bron, Alain M.
Acar, Niyazi
Creuzot-Garcher, Catherine
author_sort Seydou, Alassane
collection PubMed
description (1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesthesia, tear film breakup time (TFBUT) measurement and fluorescein corneal staining. Plasma FAs were measured in fasting blood using gas chromatography; (3) Results: A total of 740 subjects with a plasma measurement of 25 FAs were included in this study. The mean age was 82.2 ± 3.7 years, and 62.7% were women. DED was present in 35.0% of participants. We identified a plasma FAs pattern positively associated with DED, characterized by low polyunsaturated fatty acids (PUFAs), high monounsaturated fatty acids (MUFAs) and low saturated fatty acids (SFAs) levels. After adjustment for major confounders, individuals in the upper quartile of the FAs pattern scores compared with those in the lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51–4.01), p = 0.001); (4) Conclusion: In this study, we found that a plasma FAs pattern characterized by low PUFAs, high MUFAs and low SFAs was significantly associated with DED in elderly participants.
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spelling pubmed-91831642022-06-10 Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study Seydou, Alassane Arnould, Louis Gabrielle, Pierre-Henry Baudin, Florian Ghezala, Ines Ben Bron, Alain M. Acar, Niyazi Creuzot-Garcher, Catherine Nutrients Article (1) Background: To investigate the association between plasma fatty acids (FAs) and dry eye disease (DED) in an elderly population; (2) Methods: We conducted a population-based study, the Montrachet study, in individuals older than 75 years. DED was evaluated using the Schirmer I test without anesthesia, tear film breakup time (TFBUT) measurement and fluorescein corneal staining. Plasma FAs were measured in fasting blood using gas chromatography; (3) Results: A total of 740 subjects with a plasma measurement of 25 FAs were included in this study. The mean age was 82.2 ± 3.7 years, and 62.7% were women. DED was present in 35.0% of participants. We identified a plasma FAs pattern positively associated with DED, characterized by low polyunsaturated fatty acids (PUFAs), high monounsaturated fatty acids (MUFAs) and low saturated fatty acids (SFAs) levels. After adjustment for major confounders, individuals in the upper quartile of the FAs pattern scores compared with those in the lower quartile were more likely to present DED (OR 2.46 (95% CI 1.51–4.01), p = 0.001); (4) Conclusion: In this study, we found that a plasma FAs pattern characterized by low PUFAs, high MUFAs and low SFAs was significantly associated with DED in elderly participants. MDPI 2022-05-30 /pmc/articles/PMC9183164/ /pubmed/35684090 http://dx.doi.org/10.3390/nu14112290 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seydou, Alassane
Arnould, Louis
Gabrielle, Pierre-Henry
Baudin, Florian
Ghezala, Ines Ben
Bron, Alain M.
Acar, Niyazi
Creuzot-Garcher, Catherine
Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title_full Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title_fullStr Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title_full_unstemmed Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title_short Plasma Fatty Acids Pattern and Dry Eye Disease in the Elderly: The Montrachet Population-Based Study
title_sort plasma fatty acids pattern and dry eye disease in the elderly: the montrachet population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183164/
https://www.ncbi.nlm.nih.gov/pubmed/35684090
http://dx.doi.org/10.3390/nu14112290
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