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Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes

Cornus mas L., also known as cornelian cherry (CM), is a species that has long been cultivated in many different countries. In numerous scientific reports, cornelian cherry is used to treat numerous diseases and conditions. The presented study evaluated the effect of red and yellow Cornus mas L. ext...

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Autores principales: Małodobra-Mazur, Małgorzata, Cierzniak, Aneta, Ryba, Martyna, Sozański, Tomasz, Piórecki, Narcyz, Kucharska, Alicja Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183168/
https://www.ncbi.nlm.nih.gov/pubmed/35684107
http://dx.doi.org/10.3390/nu14112307
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author Małodobra-Mazur, Małgorzata
Cierzniak, Aneta
Ryba, Martyna
Sozański, Tomasz
Piórecki, Narcyz
Kucharska, Alicja Z.
author_facet Małodobra-Mazur, Małgorzata
Cierzniak, Aneta
Ryba, Martyna
Sozański, Tomasz
Piórecki, Narcyz
Kucharska, Alicja Z.
author_sort Małodobra-Mazur, Małgorzata
collection PubMed
description Cornus mas L., also known as cornelian cherry (CM), is a species that has long been cultivated in many different countries. In numerous scientific reports, cornelian cherry is used to treat numerous diseases and conditions. The presented study evaluated the effect of red and yellow Cornus mas L. extract on insulin sensitivity in adipocytes. 3T3-L1 fibroblasts as well as human SAT-derived and VAT-derived adipocytes were differentiated in vitro, and insulin resistance was induced using palmitic acid (16:0). The effect of CM fruit extract was analyzed in terms of glucose uptake and insulin signaling gene expression. In the glucose uptake test after insulin stimulation, a significant increase in glucose uptake was demonstrated in cells treated with CM fruit extracts. Furthermore, CM fruit extracts increased the expression of insulin signaling genes in adipocytes stimulated with insulin in control cells and adipocytes treated with CM extract. Additionally, a significant increase in peroxisome proliferator activated receptor gamma (PPARG) expression was observed in cells supplemented with CM extract. In conclusion, studies have shown that CM fruits can overcome insulin resistance and thus they have a positive effect on cell metabolism.
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spelling pubmed-91831682022-06-10 Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes Małodobra-Mazur, Małgorzata Cierzniak, Aneta Ryba, Martyna Sozański, Tomasz Piórecki, Narcyz Kucharska, Alicja Z. Nutrients Article Cornus mas L., also known as cornelian cherry (CM), is a species that has long been cultivated in many different countries. In numerous scientific reports, cornelian cherry is used to treat numerous diseases and conditions. The presented study evaluated the effect of red and yellow Cornus mas L. extract on insulin sensitivity in adipocytes. 3T3-L1 fibroblasts as well as human SAT-derived and VAT-derived adipocytes were differentiated in vitro, and insulin resistance was induced using palmitic acid (16:0). The effect of CM fruit extract was analyzed in terms of glucose uptake and insulin signaling gene expression. In the glucose uptake test after insulin stimulation, a significant increase in glucose uptake was demonstrated in cells treated with CM fruit extracts. Furthermore, CM fruit extracts increased the expression of insulin signaling genes in adipocytes stimulated with insulin in control cells and adipocytes treated with CM extract. Additionally, a significant increase in peroxisome proliferator activated receptor gamma (PPARG) expression was observed in cells supplemented with CM extract. In conclusion, studies have shown that CM fruits can overcome insulin resistance and thus they have a positive effect on cell metabolism. MDPI 2022-05-31 /pmc/articles/PMC9183168/ /pubmed/35684107 http://dx.doi.org/10.3390/nu14112307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Małodobra-Mazur, Małgorzata
Cierzniak, Aneta
Ryba, Martyna
Sozański, Tomasz
Piórecki, Narcyz
Kucharska, Alicja Z.
Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title_full Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title_fullStr Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title_full_unstemmed Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title_short Cornus mas L. Increases Glucose Uptake and the Expression of PPARG in Insulin-Resistant Adipocytes
title_sort cornus mas l. increases glucose uptake and the expression of pparg in insulin-resistant adipocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9183168/
https://www.ncbi.nlm.nih.gov/pubmed/35684107
http://dx.doi.org/10.3390/nu14112307
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