Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review

Ulcerative colitis (UC) is a relapsing and remitting chronic inflammatory disease of the large intestine characterized by bloody diarrhea, abdominal pain, urgency, and tenesmus. Rapid induction and maintenance of remission are the primary goals of treatment. Azathioprine (AZA), a purine analog, has...

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Detalles Bibliográficos
Autores principales: Mallick, Bipadabhanjan, Malik, Sarthak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184176/
https://www.ncbi.nlm.nih.gov/pubmed/35698683
http://dx.doi.org/10.7759/cureus.24874
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author Mallick, Bipadabhanjan
Malik, Sarthak
author_facet Mallick, Bipadabhanjan
Malik, Sarthak
author_sort Mallick, Bipadabhanjan
collection PubMed
description Ulcerative colitis (UC) is a relapsing and remitting chronic inflammatory disease of the large intestine characterized by bloody diarrhea, abdominal pain, urgency, and tenesmus. Rapid induction and maintenance of remission are the primary goals of treatment. Azathioprine (AZA), a purine analog, has been utilized as an immuno-modulator to maintain remission in UC. AZA has been used for a long time, but there is still controversy about its effectiveness, drug interactions, and side effects in people with UC. We conducted a comprehensive analysis of the literature and present a detailed insight into the role of AZA in patients with UC.
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spelling pubmed-91841762022-06-12 Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review Mallick, Bipadabhanjan Malik, Sarthak Cureus Internal Medicine Ulcerative colitis (UC) is a relapsing and remitting chronic inflammatory disease of the large intestine characterized by bloody diarrhea, abdominal pain, urgency, and tenesmus. Rapid induction and maintenance of remission are the primary goals of treatment. Azathioprine (AZA), a purine analog, has been utilized as an immuno-modulator to maintain remission in UC. AZA has been used for a long time, but there is still controversy about its effectiveness, drug interactions, and side effects in people with UC. We conducted a comprehensive analysis of the literature and present a detailed insight into the role of AZA in patients with UC. Cureus 2022-05-10 /pmc/articles/PMC9184176/ /pubmed/35698683 http://dx.doi.org/10.7759/cureus.24874 Text en Copyright © 2022, Mallick et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mallick, Bipadabhanjan
Malik, Sarthak
Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title_full Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title_fullStr Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title_full_unstemmed Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title_short Use of Azathioprine in Ulcerative Colitis: A Comprehensive Review
title_sort use of azathioprine in ulcerative colitis: a comprehensive review
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184176/
https://www.ncbi.nlm.nih.gov/pubmed/35698683
http://dx.doi.org/10.7759/cureus.24874
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