Cargando…

Permeability of the fish intestinal membrane to bulky chemicals

The ability to predict the environmental behavior of chemicals precisely is important for realizing more rational regulation. In this study, the bioaccumulation of nine chemicals of different molecular weights absorbed via the intestinal tract was evaluated in fish using the everted gut sac method....

Descripción completa

Detalles Bibliográficos
Autores principales: Miyata, Chiyoko, Matoba, Yoshihide, Mukumoto, Makiko, Nakagawa, Yoshiaki, Miyagawa, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pesticide Science Society of Japan 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184245/
https://www.ncbi.nlm.nih.gov/pubmed/35800395
http://dx.doi.org/10.1584/jpestics.D21-055
Descripción
Sumario:The ability to predict the environmental behavior of chemicals precisely is important for realizing more rational regulation. In this study, the bioaccumulation of nine chemicals of different molecular weights absorbed via the intestinal tract was evaluated in fish using the everted gut sac method. The amounts of chemicals that passed through the intestinal membrane after a 24-hr exposure were significantly decreased for chemicals with MW≥548 and D(max min)≥15.8 Å (or D(max aver)≥17.2 Å). These thresholds are consistent with those previously proposed in terms of MW (>800) and molecular size (D(max min)>15.6 Å or D(max aver)>17.1 Å) for the limit of permeable chemicals through the gill membrane. The results show that the same MW and D(max) criteria can be used to predict low bioaccumulation through both the gill membrane and the intestinal tract. These findings are helpful in reducing the need to conduct animal tests in environmental safety studies.