Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia

OBJECTIVES: To ascertain correlation between systemic hypertension and respiratory sequelae amongst infants with BPD. STUDY DESIGN: Retrospective evaluation of six-year data compared infants with severe BPD to infants with no BPD. 7-day morning blood pressure (BP) (36(0)−36(6) week) was compared wit...

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Autores principales: Sehgal, Arvind, Elsayed, Kristy, Nugent, Matilda, Varma, Suraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184283/
https://www.ncbi.nlm.nih.gov/pubmed/35354941
http://dx.doi.org/10.1038/s41372-022-01372-y
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author Sehgal, Arvind
Elsayed, Kristy
Nugent, Matilda
Varma, Suraj
author_facet Sehgal, Arvind
Elsayed, Kristy
Nugent, Matilda
Varma, Suraj
author_sort Sehgal, Arvind
collection PubMed
description OBJECTIVES: To ascertain correlation between systemic hypertension and respiratory sequelae amongst infants with BPD. STUDY DESIGN: Retrospective evaluation of six-year data compared infants with severe BPD to infants with no BPD. 7-day morning blood pressure (BP) (36(0)−36(6) week) was compared with 95th centile cut-offs. RESULTS: 57 infants with BPD were compared with 114 infants with no BPD. Gestation and birthweight were comparable (median [interquartile range], (27 [25, 28] vs. 26.5 weeks [25, 28], p = 0.7 and 706 g [611, 884] vs. 730 [630, 895]), p = 0.1. Number of infants having BP ≥ 95th centile was significantly higher in BPD cohort (systolic BP, 23/57 [40.3%] vs. 3/114 [2.6%], p < 0.001 & mean arterial BP, 26/57 [46%] vs. 3/114 [2.6%], p < 0.001). Amongst BPD infants, higher BP was associated with longer duration of respiratory support (median [range], 109 days [81–138] vs. 87 [58–109], p < 0.001). CONCLUSIONS: Infants with severe BPD had higher BP compared to those without BPD.
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spelling pubmed-91842832022-06-11 Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia Sehgal, Arvind Elsayed, Kristy Nugent, Matilda Varma, Suraj J Perinatol Article OBJECTIVES: To ascertain correlation between systemic hypertension and respiratory sequelae amongst infants with BPD. STUDY DESIGN: Retrospective evaluation of six-year data compared infants with severe BPD to infants with no BPD. 7-day morning blood pressure (BP) (36(0)−36(6) week) was compared with 95th centile cut-offs. RESULTS: 57 infants with BPD were compared with 114 infants with no BPD. Gestation and birthweight were comparable (median [interquartile range], (27 [25, 28] vs. 26.5 weeks [25, 28], p = 0.7 and 706 g [611, 884] vs. 730 [630, 895]), p = 0.1. Number of infants having BP ≥ 95th centile was significantly higher in BPD cohort (systolic BP, 23/57 [40.3%] vs. 3/114 [2.6%], p < 0.001 & mean arterial BP, 26/57 [46%] vs. 3/114 [2.6%], p < 0.001). Amongst BPD infants, higher BP was associated with longer duration of respiratory support (median [range], 109 days [81–138] vs. 87 [58–109], p < 0.001). CONCLUSIONS: Infants with severe BPD had higher BP compared to those without BPD. Nature Publishing Group US 2022-03-30 2022 /pmc/articles/PMC9184283/ /pubmed/35354941 http://dx.doi.org/10.1038/s41372-022-01372-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sehgal, Arvind
Elsayed, Kristy
Nugent, Matilda
Varma, Suraj
Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title_full Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title_fullStr Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title_full_unstemmed Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title_short Sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
title_sort sequelae associated with systemic hypertension in infants with severe bronchopulmonary dysplasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184283/
https://www.ncbi.nlm.nih.gov/pubmed/35354941
http://dx.doi.org/10.1038/s41372-022-01372-y
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AT nugentmatilda sequelaeassociatedwithsystemichypertensionininfantswithseverebronchopulmonarydysplasia
AT varmasuraj sequelaeassociatedwithsystemichypertensionininfantswithseverebronchopulmonarydysplasia

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